Case-Control Study of the Effects of Gut Microbiota Composition on Neurotransmitter Metabolic Pathways in Children With Attention Deficit Hyperactivity Disorder

Frontiers in Neuroscience
Lin WanGuang Yang

Abstract

Attention-deficit/hyperactivity disorder (ADHD) is a neuropsychiatric condition that may be related to an imbalance of neural transmitters. The gut microbiota is the largest ecosystem in the human body, and the brain-gut axis theory proposes that the gut microbiome can affect brain function in multiple ways. The purpose of this study was to explore the gut microbiota in children with ADHD and assess the possible role of the gut microbiota in disease pathogenesis to open new avenues for ADHD treatment. A case-control design was used. We enrolled 17 children aged 6-12 years with ADHD who were treated in the Pediatric Outpatient Department of the First Medical Center of the Chinese PLA General Hospital from January to June, 2019. Seventeen children aged 6-12 years were selected as the healthy control (HC) group. Fecal samples of cases and controls were analyzed by shotgun metagenomics sequencing. Alpha diversity and the differences in the relative abundances of bacteria were compared between the two groups. Functional annotations were performed for the microbiota genes and metabolic pathways were analyzed using the Kyoto Encyclopedia of Genes and Genomes (KEGG). There was no significant difference in the alpha diversity of gut mic...Continue Reading

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Citations

Feb 18, 2021·Annals of General Psychiatry·Alverina Cynthia SukmajayaYunias Setiawati
Feb 10, 2021·Progress in Neuro-psychopharmacology & Biological Psychiatry·Anna KalenikTomasz Wolańczyk
May 7, 2021·Frontiers in Neuroendocrinology·Aranyak GoswamiRenato Polimanti
Jul 28, 2020·CNS & Neurological Disorders Drug Targets·Qin HuangJian Xia
Jul 10, 2021·Translational Psychiatry·Vanesa RicharteJosep Antoni Ramos-Quiroga

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Software Mentioned

SPSS
HUMAnN2
R
Phylogenetic by Reconstruction of Unobserved ( PICRUSt )
Bowtie2
ade4
KneadData
MetaPhlAn2
PERMANOVA
Qubit

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