Case-control study on influence of methionine, nitrite, and salt on gastric carcinogenesis in northern Italy

Nutrition and Cancer
C La VecchiaA Decarli

Abstract

A new mutagen, 2-chloro-4-methylthiobutanoic acid, has recently been identified from a nitrite-treated Japanese salted fish. Its structure suggests that it derives from methionine in the presence of salt and nitrite. We thus considered the interaction between intake of methionine, salt, and nitrites on gastric cancer risk using data from a case-control study conducted in Northern Italy on 746 cases of incident histologically confirmed gastric cancer and 2,053 controls in hospital for acute nonneoplastic nondigestive tract disorders. Compared with subjects reporting low-methionine and low-salt intake, the odds ratios (ORs) were 2.4 [95% confidence interval (CI) = 1.5 - 4.0] for those reporting low-salt and high-methionine, 1.5 (95% CI = 1.0 - 2.2) for those with high-salt and low-methionine, and 2.8 (95% CI = 1.9 - 4.2) for those with high-salt and high-methionine intake. Likewise, with reference to nitrites, compared with subjects with low-methionine and low-nitrite intake, the ORs were 1.9 (95% CI = 1.3 - 2.6) in the high-methionine and low-nitrite stratum, 1.5 (95% CI = 1.0 - 2.1) in the low-methionine and high-nitrite stratum, and 2.5 (95% CI = 1.9 - 3.2) in the high-methionine and high-nitrite stratum. All these estimates w...Continue Reading

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Citations

Aug 2, 2008·Annals of Oncology : Official Journal of the European Society for Medical Oncology·C PelucchiC La Vecchia
May 14, 2009·World Journal of Gastroenterology : WJG·Xiao-Qin WangHong Yan
Nov 16, 2010·Annals of Epidemiology·Matteo MalvezziEva Negri
Mar 28, 2002·European Journal of Cancer Prevention : the Official Journal of the European Cancer Prevention Organisation (ECP)·M ConioA Giacosa
Nov 15, 2000·European Journal of Cancer Prevention : the Official Journal of the European Cancer Prevention Organisation (ECP)·C La Vecchia, S Franceschi
Jan 24, 2007·Gastroenterology·Albert B Lowenfels, Patrick Maisonneuve
Apr 22, 2009·International Journal of Cancer. Journal International Du Cancer·Paola BertuccioCarlo La Vecchia
May 19, 2009·International Journal of Cancer. Journal International Du Cancer·Raúl U Hernández-RamírezLizbeth López-Carrillo
Jul 1, 1997·Journal of the American Dietetic Association·J H Weisburger
Aug 15, 2012·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Nathan S BryanPaolo Boffetta
Feb 3, 2012·Clinical Nutrition : Official Journal of the European Society of Parenteral and Enteral Nutrition·Lanfranco D'EliaPasquale Strazzullo
Sep 27, 2012·Arquivos De Gastroenterologia·Raphael Mendonça Guimarães, Camila Drumond Muzi
Oct 14, 2014·World Journal of Gastroenterology : WJG·Francesco RussoAntonella Orlando
Jul 26, 2006·World Journal of Gastroenterology : WJG·Paula Jakszyn, Carlos-Alberto Gonzalez
Mar 12, 2010·The American Journal of Clinical Nutrition·Jeongseon KimByung-Ho Nam
May 3, 2014·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Sun-Seog KweonMartha J Shrubsole
Jun 6, 2000·The American Journal of Clinical Nutrition·J H Weisburger

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