Case-control study on risk factors for acute hepatitis E in Germany, 2012 to 2014

Euro Surveillance : Bulletin Européen Sur Les Maladies Transmissibles = European Communicable Disease Bulletin
Mirko FaberK Stark

Abstract

BackgroundNotified cases of hepatitis E have increased 40-fold in the past 10 years in Germany. Food safety is a major concern as hepatitis E virus (HEV) RNA has been detected in ready-to-eat retail-level food products. The objective of this case-control study was to assess risk factors for autochthonous symptomatic hepatitis E and explore reasons for delays in diagnosis. Methods: Demographic, clinical and exposure data from notified hepatitis E cases and individually matched population controls were collected in semi-standardised telephone interviews. Conditional logistic regression analysis was used to calculate matched odds ratios (mOR) and population attributable fractions (PAF). Results: In total, 270 cases and 1,159 controls were included (mean age 53 years, 61% men in both groups). Associated with disease were: consumption of undercooked pork liver, pork, wild boar meat, frankfurters, liver sausage and raw vegetables; contact with waste water (occupational) and various host factors (mORs between 1.9 and 34.1, p value < 0.03). PAF for frankfurters and liver sausage were 17.6%, and 23.6%, respectively. There were statistically significant differences in the clinical presentation and hospitalisation proportion of acute hepa...Continue Reading

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Citations

Nov 28, 2018·Foodborne Pathogens and Disease·Maria Fredriksson-Ahomaa
Jun 22, 2019·BMC Infectious Diseases·Joachim DennerDieter Glebe
Mar 17, 2020·Food and Environmental Virology·Sophia BeyerHans-Christoph Selinka
Jul 13, 2019·Frontiers in Microbiology·Antonio Rivero-JuarezAntonio Rivero
Mar 16, 2021·Frontiers in Microbiology·Antonio Rivero-JuarezAntonio Rivero
Apr 27, 2021·Food and Environmental Virology·K HriskovaK Katz
Mar 23, 2020·Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation·Elisa FurfaroMalgorzata Mikulska
Jul 3, 2021·Animals : an Open Access Journal From MDPI·Patricia BarrosoJoaquín Vicente
Jul 27, 2021·Frontiers in Microbiology·Antonio Rivero-JuarezAntonio Rivero
Sep 2, 2021·One Health·Maria Casares-JimenezAntonio Rivero
Jan 5, 2022·Bundesgesundheitsblatt, Gesundheitsforschung, Gesundheitsschutz·Reimar JohneAlexander Falkenhagen

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Methods Mentioned

BETA
PCR
X-ray
biopsy

Software Mentioned

STATA

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