Case-controlled study comparing peri-operative and cancer-related outcomes after major hepatectomy and parenchymal sparing hepatectomy for metastatic colorectal cancer

HPB : the Official Journal of the International Hepato Pancreato Biliary Association
J T LordanRobert P Sutcliffe

Abstract

Liver resection is potentially curative in selected patients with colorectal liver metastases (CLM). There has been a trend towards parenchyma sparing hepatectomy (PSH) rather than major hepatectomy (MH) due to lower perioperative morbidity. Although data from retrospective series suggest that long-term survival after PSM are similar to MH, these reports may be subject to selection bias. The aim of this study was to compare outcomes of PSH and MH in a case-controlled study. 917 consecutive patients who underwent liver resection for CLM during 2000-2010 were identified from a prospective database. 238 patients who underwent PSH were case-matched with 238 patients who had MH, for age, gender, tumour number, maximum tumour diameter, primary Dukes' stage, synchronicity and chemotherapy status using a propensity scoring system. Peri-operative outcomes, recurrence and long-term survival were compared. Fewer PSH patients received peri-operative blood transfusions (p < 0.0001). MH patients had greater incidence of complications (p = 0.04), grade III/IV complications (p = 0.01) and 90-day mortality (p = 0.03). Hospital stay was greater in the MH group (p = 0.04). There was no difference in overall/disease-free survival. Patients with re...Continue Reading

Citations

Mar 27, 2018·Journal of Clinical and Translational Hepatology·Amir A Rahnemai-AzarTimothy M Pawlik
Oct 27, 2018·World Journal of Gastrointestinal Oncology·Emilio De RaffeleFrancesco Minni
Dec 7, 2018·Surgical Laparoscopy, Endoscopy & Percutaneous Techniques·Airazat M KazaryanBjørn Edwin
Jul 19, 2020·Nature Reviews. Gastroenterology & Hepatology·Henrik PetrowskyPierre-Alain Clavien
Nov 18, 2020·Journal of Hepato-biliary-pancreatic Sciences·Masakazu YamamotoTadahiro Takada
Mar 19, 2019·European Journal of Surgical Oncology : the Journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology·G DesolneuxS Evrard
Apr 17, 2021·Acta chirurgica Belgica·Thomas ApersThiery Chapelle

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