Case fatality among infants with congenital malformations by lethality

Birth Defects Research. Part A, Clinical and Molecular Teratology
Kirk A BolRussell S Kirby

Abstract

Infant mortality rates continue to show that congenital anomalies are the leading cause of infant death in the United States. However, studies of factors contributing to increased mortality across different types of congenital anomalies have been limited. The objective of this study was to assess whether the likelihood of infant mortality varied by maternal race and ethnic group while considering the severity of the birth defect. A retrospective cohort analysis was conducted using data from Colorado's statewide, population-based birth defects surveillance system (CRCSN). The cohort included infants, born between 1995 and 2000 to Colorado resident mothers, who were diagnosed with major congenital malformations stratified by degree of lethality. Multiple logistic regression was performed for each level of lethality, and included the following potential explanatory variables: maternal race/ethnicity, clinical gestation, birth weight, maternal education level, maternal age, and sex of child. Within the low/very low lethality cohort, maternal race/ethnicity of Black/non-Hispanic was associated with increased risk of infant mortality, OR 2.81 (1.41-5.19), as were low and very low birth weight, OR 2.21 (1.12-4.04) and 19.31 (11.84-31....Continue Reading

References

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Citations

Nov 13, 2015·American Journal of Public Health·Callie A M AttaAmy Metcalfe
Oct 6, 2006·Birth Defects Research. Part A, Clinical and Molecular Teratology·Quanhe YangMargaret A Honein
Aug 5, 2010·Birth Defects Research. Part A, Clinical and Molecular Teratology·Ying WangCharlotte M Druschel
Jul 31, 2010·Birth Defects Research. Part A, Clinical and Molecular Teratology·Wendy N NembhardMark A Canfield

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Birth defects encompass structural and functional alterations that occur during embryonic or fetal development and are present since birth. The cause may be genetic, environmental or unknown and can result in physical and/or mental impairment. Here is the latest research on birth defects.