Case fatality and population mortality associated with anaphylaxis in the United States

The Journal of Allergy and Clinical Immunology
Larry MaLarry Borish

Abstract

Anaphylaxis is a serious allergic reaction that can cause death; however, the actual risk of death is unclear. We sought to estimate the case fatality rate among hospitalizations or emergency department (ED) presentations for anaphylaxis and the mortality rate associated with anaphylaxis for the general population. This was a population-based epidemiologic study using 3 national databases: the Nationwide Inpatient Sample (NIS; 1999-2009), the Nationwide Emergency Department Sample (NEDS; 2006-2009), and Multiple Cause of Death Data (MCDD; 1999-2009). Sources for these databases are hospital and ED discharge records and death certificates, respectively. Case fatality rates were between 0.25% and 0.33% among hospitalizations or ED presentations with anaphylaxis as the principal diagnosis (NIS+NEDS, 2006-2009). These rates represent 63 to 99 deaths per year in the United States, approximately 77% of which occurred in hospitalized patients. The rate of anaphylaxis-related hospitalizations increased from 21.0 to 25.1 per million population between 1999 and 2009 (annual percentage change, 2.23%; 95% CI, 1.52% to 2.94%), contrasting with a decreasing case fatality rate among hospitalizations (annual percentage change, -2.35%; 95% CI, ...Continue Reading

References

Jan 1, 1997·Pediatrics·S D Dibs, M D Baker
Aug 19, 1999·The Journal of Allergy and Clinical Immunology·M W YocumM D Silverstein
Jan 25, 2003·Current Allergy and Asthma Reports·Matthew J Matasar, Alfred I Neugut
Feb 28, 2004·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·A HelblingW J Pichler
Mar 10, 2004·The Journal of Allergy and Clinical Immunology·Kari BohlkeUNKNOWN Vaccine Safety Datalink Team
Feb 25, 2005·Allergy·D A Moneret-VautrinG Kanny
Dec 15, 2006·Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology·Phil LiebermanF Estelle R Simons
Apr 17, 2008·Cancer Causes & Control : CCC·D TrichopoulosH O Adami
Aug 12, 2008·Allergy·S F KempUNKNOWN World Allergy Organization ad hoc Committee on Epinephrine in Anaphylaxis
Oct 23, 2008·Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology·Robert Y LinFarzana Nurruzzaman
Jun 10, 2009·Current Opinion in Allergy and Clinical Immunology·Mimi L K TangKatrina Allen
Oct 8, 2009·American Journal of Public Health·Liyuan MaRobbin F Itzler
Jan 16, 2010·Annals of Emergency Medicine·Pamela L OwensRyan L Mutter
Jun 22, 2010·Allergy·M Ben-Shoshan, A E Clarke
Aug 10, 2010·The Journal of Allergy and Clinical Immunology·Phillip LiebermanDana Wallace
Nov 3, 2010·Current Allergy and Asthma Reports·Zuber D MullaMichael R Simon
Jun 15, 2011·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·J K Lee, P Vadas

❮ Previous
Next ❯

Citations

Jun 21, 2014·Current Allergy and Asthma Reports·A MatitoL Escribano
Apr 28, 2016·Clinical Pharmacology in Drug Development·Alan Wayne Jones
Jan 7, 2016·Immunity, Inflammation and Disease·Nofar KimchiMoshe Ben-Shoshan
Dec 22, 2015·The Journal of Allergy and Clinical Immunology·Meghan N JeffresGarrett E Schramm
Nov 4, 2015·The World Allergy Organization Journal·F Estelle R SimonsAziz Sheikh
Dec 23, 2015·The Journal of Allergy and Clinical Immunology·Anni Nørgaard JeppesenHenrik Toft Sørensen
Sep 30, 2014·Pediatric Allergy and Immunology : Official Publication of the European Society of Pediatric Allergy and Immunology·Julie WangAnna Nowak-Węgrzyn
Aug 12, 2014·Pharmacoepidemiology and Drug Safety·Stephen J W Evans, Hubert G M Leufkens
Oct 3, 2015·Hospital Pediatrics·Katherine McMurray, Matthew Garber
Jul 1, 2015·The Journal of Allergy and Clinical Immunology. in Practice·Megan K FordJohn R Cohn
Sep 12, 2015·Clinical Reviews in Allergy & Immunology·Joyce E Yu, Robert Y Lin
Feb 24, 2015·Pediatric Allergy and Immunology : Official Publication of the European Society of Pediatric Allergy and Immunology·Garrick MokWaleed Alqurashi
Dec 17, 2014·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·M A Tejedor AlonsoM V Múgica García
Mar 27, 2015·Allergy·M A Tejedor-AlonsoA Gil de Miguel
May 21, 2015·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Kimberly G BlumenthalRochelle P Walensky
Jul 19, 2015·The Journal of Allergy and Clinical Immunology·Raymond James MullinsMimi L K Tang
Jun 24, 2015·Clinical and Molecular Allergy : CMA·Corrado MironeElide A Pastorello
Feb 11, 2015·The Journal of Allergy and Clinical Immunology·Scott H Sicherer, Donald Y M Leung
Oct 5, 2014·Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology·Susan J KimBruce J Goldberg
Oct 5, 2014·The Journal of Allergy and Clinical Immunology·Elina JerschowAileen P McGinn
Jun 28, 2016·The Journal of Allergy and Clinical Immunology·Juho E KivistöMika J Mäkelä
May 5, 2016·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·R J MullinsD E Campbell
Aug 25, 2016·The American Journal of Medicine·Leonard Fromer
Nov 8, 2016·The Journal of Allergy and Clinical Immunology. in Practice·Megan S MotosueRonna L Campbell
Jan 15, 2017·Orphanet Journal of Rare Diseases·Luciana Kase TannoUNKNOWN Joint Allergy Academies
Mar 6, 2017·Internal Medicine Journal·Mimi L K Tang, Raymond J Mullins
Mar 12, 2017·The Journal of Allergy and Clinical Immunology·Guillaume PouesselStéphane Leteurtre
Apr 6, 2017·Current Opinion in Allergy and Clinical Immunology·Alessandro Fiocchi, Motohiro Ebisawa
Feb 9, 2017·Clinical and Molecular Allergy : CMA·Maria Teresa VenturaGiorgio Walter Canonica
May 12, 2017·Pediatric Critical Care Medicine : a Journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies·Nnenna O ChimeUNKNOWN International Network for Simulation-based Pediatric Innovation, Research and Education (INSPIRE) Collaborative
Jan 20, 2018·Prehospital Emergency Care : Official Journal of the National Association of EMS Physicians and the National Association of State EMS Directors·Emily AndrewKaren Smith
Sep 12, 2018·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·Miguel A Tejedor-AlonsoNuria Alberti-Masgrau
Oct 6, 2018·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·Guillaume PouesselLuciana K Tanno
Dec 12, 2018·Prehospital Emergency Care : Official Journal of the National Association of EMS Physicians and the National Association of State EMS Directors·Kathleen GrisantiJulie C Leonard
Feb 5, 2019·International Forum of Allergy & Rhinology·Mohamad R ChaabanYong-Fang Kuo
Jul 12, 2019·Forensic Science, Medicine, and Pathology·Pilar Martínez-FernandezMiguel A Tejedor-Alonso
Jun 18, 2018·Archives of Disease in Childhood·Katherine Anagnostou, Paul J Turner
May 5, 2020·Journal of the American Veterinary Medical Association·M Ryan SmithMark Mitchell
May 5, 2020·Allergy·Maria Beatrice BilòDonatella Bignardi
Aug 5, 2016·Current Opinion in Allergy and Clinical Immunology·Paul J Turner, Dianne E Campbell
Jul 19, 2019·Current Opinion in Allergy and Clinical Immunology·Pasquale ComberiatiDiego G Peroni

❮ Previous
Next ❯

Related Concepts

Related Feeds

Anaphylaxis

Anaphylaxis is a serious allergic reaction that is rapid in onset and may cause death.

Allergy and Asthma

Allergy and asthma are inflammatory disorders that are triggered by the activation of an allergen-specific regulatory t cell. These t cells become activated when allergens are recognized by allergen-presenting cells. Here is the latest research on allergy and asthma.