Case-finding in primary care for coeliac disease: Accuracy and cost-effectiveness of a rapid point-of-care test

United European Gastroenterology Journal
Maria EsteveFernando Fernández-Bañares

Abstract

An on-site, rapid, fingertip, whole-blood point-of-care test (POCT) is attractive for active case-finding of coeliac disease (CD) in primary care because of its simplicity. The aim of this article is to assess the usefulness and cost-effectiveness of adult case-finding using a POCT based on deamidated gliadin peptide antibodies (IgA/IgG-DGP) in primary care for CD diagnosis. A case-finding study for CD was conducted by using an easy-to-use, on-site, whole-blood for IgA/IgG-DGP-based fingertip POCT compared with tTG2 in 350 individuals. Sample size was calculated based on 0.28% prevalence in the reference population. Duodenal biopsies for histology, intraepithelial lymphocytes and in situ deposition of tTG2 were obtained if tTG2 and/or POCT were positive. Accuracy and cost-effectiveness of strategies using serology or POCT were calculated. Prevalence of CD was 1.14% (95% CI, 0.3-3.4), almost double what was previously observed. Four patients were diagnosed with CD. tTG2 was positive in three (0.85%) and POCT in 29 (8.2%). Sensitivity of POCT for CD was 100%, specificity 93%, PPV 14%, and NPV 100%. POCT followed by duodenal biopsy was the most cost-effective approach in our setting (standard diagnosis: €13,033/case; POCT + duoden...Continue Reading

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Citations

Sep 18, 2018·PharmacoEconomics·Elizabeth S MearnsBenjamin Lebwohl
Nov 12, 2019·American Journal of Reproductive Immunology : AJRI·Diana AlecsandruConcepción Núñez
Apr 26, 2020·Analytical and Bioanalytical Chemistry·E Cristina PeláezLaura M Lechuga
Jan 7, 2021·PharmacoEconomics Open·Deon LingervelderMaarten J IJzerman
Sep 29, 2019·Inflammatory Intestinal Diseases·Louise GrodeCecilia Ramlau-Hansen

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Methods Mentioned

BETA
biopsy

Software Mentioned

Simtomax®

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