Case of autoimmune polyglandular syndrome type 2: how we uncovered the diagnosis

BMJ Case Reports
Akhila Arya P VRishi Raj

Abstract

A 24-year-old man with no significant medical history presented to the medical clinic with vomiting and giddiness for 2 days, loss of appetite for 1 month and progressive fatigability for the preceding 4 months. On examination, he was found to be hypotensive and was admitted to the hospital for work-up. Considering his abnormal labs and physical findings, he was worked up and was diagnosed with primary adrenal insufficiency. On further work-up for the aetiology of his Addison's disease, he was found to have concurrent autoimmune thyroiditis and vitiligo. A final diagnosis of autoimmune polyglandular syndrome type 2 was made. The patient was started on hormone replacement therapy and reported improvement of symptoms on 3-month follow-up visit.

References

Jul 24, 2004·Clinical and Experimental Immunology·C BetterleF Presotto
Mar 22, 2018·The New England Journal of Medicine·Eystein S HusebyeOlle Kämpe

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