Abstract
We managed a peculiar case of lymphoma showing immunohistochemical overexpression of cyclin D1. At initial examination the patient had meningeal lymphomatosis and general lymphadenopathy. Histologic examination of biopsy specimens of inguinal lymph nodes showed tumor cells and vague nodular growth resembling lymphoblasts. The results of flow cytometric analysis were positive for CD10, CD20, CD103, and immunoglobulin G (IgG) and Ig kappa and were negative for CD5, CD23, and terminal deoxynucleotidyl transferase activity. Results of immunohistochemical analysis of paraffin-embedded specimens were positive for cyclin D1 and Bcl2 in the tumor cells. Sixty percent of tumor cells had positive results for MIB1/Ki67. Cytogenetic and molecular studies revealed tumor cells simultaneously had t(14;18)(q32;q21), t(11;22)(q13;q11), t(8;14)(q24;q32), and t(3;14)(q27;q32) with the rearrangement of BCL1, BCL2, BCL6, and c-MYC genes. Lymphadenopathy showed a quick and complete response to doxorubicin-containing systemic chemotherapy with rituximab, but the central nervous system disease progressed and killed the patient.
References
Apr 11, 1991·Nature·T MotokuraA Arnold
Nov 22, 1991·Science·E SolomonA D Goddard
Jul 1, 1988·Proceedings of the National Academy of Sciences of the United States of America·M CrescenziS J Korsmeyer
Jun 21, 1985·Science·Y TsujimotoC M Croce
May 23, 1985·Nature·Y TsujimotoC M Croce
Dec 20, 1980·Nucleic Acids Research·N TakahashiT Honjo
Jul 1, 1994·Leukemia & Lymphoma·U JaegerR Kusec
Oct 1, 1993·British Journal of Haematology·H KomatsuC Mikuni
Aug 1, 1993·Leukemia & Lymphoma·A KarsanD E Horsman
Nov 26, 1996·Proceedings of the National Academy of Sciences of the United States of America·P L BergsagelW M Kuehl
May 1, 1997·Leukemia·H NakamuraM Tomonaga
Dec 31, 1997·The American Journal of Surgical Pathology·S NakamuraT Suchi
Apr 22, 1999·Annals of Hematology·R OinonenE Elonen
Dec 14, 2002·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Suyang HaoL Jeffrey Medeiros
Jan 29, 2003·Cancer Genetics and Cytogenetics·Kenichi NomuraMasafumi Taniwaki
Feb 13, 2003·American Journal of Clinical Pathology·Henry Y DongJames Weisberger
May 31, 2003·International Journal of Hematology·Martin J S Dyer
Citations
Feb 2, 2010·The American Journal of Surgical Pathology·Matija SnuderlAliyah R Sohani
Jun 19, 2009·Haematologica·Naoto TomitaIkuo Miura
May 25, 2011·Haematologica·Masao NakagawaMasao Seto
Apr 6, 2011·Leukemia & Lymphoma·Katherine GeiersbachShashirekha Shetty
Dec 19, 2006·Cancer Genetics and Cytogenetics·Huan-You WangAdam Bagg
Jul 29, 2006·Pathology International·Tetsuya Murata
Nov 2, 2012·European Journal of Haematology·Masaya ShimanukiHideki Nakakuma
May 9, 2015·Cancer Genetics·Prasad R KoduruFranklin Fuda
Apr 19, 2006·Oncogene·P RuminyC Bastard
Dec 17, 2020·HemaSphere·Jinjun ChengElaine S Jaffe