PMID: 9185918Jun 1, 1997Paper

Case of malignant lymphoma associated with primary systemic plasmacytosis with polyclonal hypergammaglobulinemia

The American Journal of Dermatopathology
Y Nitta

Abstract

Systemic plasmacytosis (SP), which has a histologic appearance similar to that of multicentric Castleman's disease (MCD), is also known as benign plasma cell proliferation with polyclonal hypergammaglobulinemia, cutaneous plasmacytosis, and/or generalized plasmacytic lymphadenopathy. The prognosis of SP reportedly has been good. A 59-year-old Japanese man was treated for multiple cutaneous lesions of his trunk as well as polyclonal hypergammaglobulinemia. A skin biopsy showed infiltration of lymphocytes and polyclonal plasma cells in the dermis. The patient developed enlarged superficial lymph nodes 5 years later, and T-cell lymphoma, diffuse mixed type, was diagnosed. At that time, his cutaneous plasmacytosis remained but the polyclonal hypergammaglobulinemia had resolved. Ours is the first reported case of SP to be complicated by the development of T-cell lymphoma.

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Citations

Jun 6, 2002·Journal of the European Academy of Dermatology and Venereology : JEADV·M Aricò, M R Bongiorno
Jul 26, 2002·The American Journal of Dermatopathology·Hesham M AminDan Jones
Apr 21, 2006·The American Journal of Dermatopathology·Anu G JayaramanSabine Kohler
Jan 19, 2011·The American Journal of Dermatopathology·Joyce Ss LeeSee Ket Ng
Aug 12, 2006·Dermatology : International Journal for Clinical and Investigative Dermatology·Christian HafnerThomas Vogt
Jan 31, 2013·Journal of the American Academy of Dermatology·Rie HondaAkira Ishiko
Sep 16, 2008·The Journal of Dermatology·Hui-Jun MaDong-Guang Li
Nov 14, 2006·Journal of the American Academy of Dermatology·Aimee L LeonardFiliz Sen
May 29, 2015·International Journal of Dermatology·Pei-Hsuan LuTseng-Tong Kuo
May 18, 2017·Journal of Veterinary Internal Medicine·B O BoostromD H Thamm
May 17, 2019·Journal of Cutaneous Pathology·Noreen M WalshLorenzo Cerroni

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