Case of Merkel cell carcinoma in a patient with pre-existing ILD.

Journal for Immunotherapy of Cancer
Rohan ManiarRichard Carvajal

Abstract

Merkel cell carcinoma (MCC) is a rare neuroendocrine tumor of the skin with high rates of local recurrence and distant metastases despite treatment with traditional cytotoxic chemotherapies. The recent advances in immunotherapy, including the use of immune checkpoint blockade (ICB) has revolutionized treatment for this disease and resulted in durable responses for some patients. However, many patients, due to underlying conditions, have been insufficiently evaluated for potential use of immunotherapy. Here we present a case of ICB treatment with Programmed cell death protein 1 (PD-1) inhibition in a patient with underlying interstitial lung disease (ILD) and a new diagnosis of MCC. Through a multidisciplinary approach, we were able to maintain close monitoring with serial clinical and radiographical follow-up. The patient achieved a complete response though unrelated medical issues resulting in a treatment hold. At the last follow-up, the patient continued to experience a durable response without evidence of recurrence. This case describes the use of pembrolizumab, a PD-1 inhibitor, for the treatment of MCC in a patient with underlying ILD. The use of active surveillance with a multidisciplinary approach resulted in successful ...Continue Reading

References

Nov 18, 2003·British Journal of Clinical Pharmacology·N R Labiris, M B Dolovich
Apr 20, 2016·The New England Journal of Medicine·Paul T NghiemMartin A Cheever
Sep 21, 2016·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Jarushka NaidooMatthew D Hellmann
Jun 21, 2017·Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer·Monica Khunger, Vamsidhar Velcheti
Aug 26, 2017·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·Daichi FujimotoKeisuke Tomii
Oct 7, 2017·Cancer Immunology, Immunotherapy : CII·Daniel FranzenMalcolm Kohler
Nov 6, 2017·Journal of the American Academy of Dermatology·Kelly G PaulsonPaul Nghiem
Dec 13, 2017·Journal of the American Academy of Dermatology·Tiffany L TelloSiegrid S Yu
Feb 7, 2019·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Paul NghiemSuzanne L Topalian

❮ Previous
Next ❯

Methods Mentioned

BETA
biopsy

Related Concepts

Related Feeds

Cancer Immunotherapy

Cancer immunotherapy is an important field of research that is looking at controlling cancer and tumor growth by activating the individuals own immune system. Recent studies have utilized chimeric antigen receptor t-cell therapy, immune checkpoint inhibitors and neoantigen vaccines. Discover the latest research on cancer immunotherapy here.

Related Papers

Clinical Cancer Research : an Official Journal of the American Association for Cancer Research
Aric ColungaPaul Nghiem
Archives of Dermatological Research
Marianna BabadzhanovJohn Carucci
F1000Research
Caitlin G RobinsonSiegrid S Yu
Dermatologic Clinics
Drew A Emge, Adela R Cardones
Current Treatment Options in Oncology
Kotaro Nagase, Yutaka Narisawa
© 2021 Meta ULC. All rights reserved