Case Report: Anti-N-Methyl-D-Aspartate Receptor Encephalitis in an Elderly Patient With Primary Sjögren's Syndrome.

Frontiers in Neurology
Xia LiYi Zhao

Abstract

Neurological manifestations of primary Sjögren's syndrome (SS) are diverse involving the peripheral and central nervous system. Anti-N-methyl-D-aspartate receptor (NMDAR) encephalitis, as the most prevalent autoimmune encephalitis, was rarely reported to be complicated with primary SS. Herein, we present an elderly patient with a 15-year history of primary SS presenting with progressive cognitive dysfunction due to anti-NMDAR encephalitis that was once misdiagnosed as primary degenerative dementia. Early recognition of anti-NMDAR encephalitis and initiation of treatment with steroids and immunosuppressant gained a favorable outcome. Our findings enhance the awareness that autoimmune encephalitis should be taken into account in the patients with primary SS presenting with progressive cognitive impairment.

References

Aug 29, 2013·Arthritis and Rheumatism·Maria B LauvsnesRoald Omdal
Jun 21, 2015·Neurology·Dean M WingerchukUNKNOWN International Panel for NMO Diagnosis
Feb 26, 2016·Lancet Neurology·Francesc GrausJosep Dalmau
Oct 30, 2016·International Journal of Rheumatic Diseases·Mehmet Engin TezcanBerna Goker
Jul 28, 2016·Multiple Sclerosis and Related Disorders·Jing-Jing LuoYi-Ning Huang
Mar 1, 2018·The New England Journal of Medicine·Josep Dalmau, Francesc Graus
Mar 8, 2018·The New England Journal of Medicine·Xavier Mariette, Lindsey A Criswell
Aug 1, 2018·Current Rheumatology Reviews·Iván Posso-OsorioGabriel J Tobón
Nov 19, 2019·Frontiers in Neurology·Jing ZhaoHongzhi Guan
Mar 13, 2020·Neurology·Eugenia Martinez-HernandezJosep Dalmau

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