Case Report: Bazex Syndrome Associated With Pulmonary Adenocarcinoma

Medicine
Jing ZhaoJian-Hua Wu

Abstract

Bazex syndrome, a rare paraneoplastic syndrome characterized by psoriasiform eruptions, palmoplantar keratosis, and symmetric onychodystrophy, is most prevalent with squamous cell carcinomas of the upper aerodigestive tract.Here, we reported an uncommon case of Bazex syndrome about an 83-year-old man with pulmonary adenocarcinoma and osseous metastasis, Physical examination found psoriasiform eruptions on the nose, cheeks, ears, knees, and the dorsa of interphalangeal joints, along with plantar keratosis and symmetric onychodystrophy involving hands and feet. Imaging analyses pulmonary adenocarcinoma with both local metastatic nodules and osseous metastasis.Symptomatic treatment with topical corticosteroids and oral retinoids showed no improvement. A 4-month follow-up showed that Gefitinib, an epidermal growth factor receptor tyrosine kinase inhibitor, successfully reduced primary tumor size and alleviated cutaneous lesions.Our report here highlighted a potential correlation between pulmonary adenocarcinoma and Bazex syndrome, which is characterized by hallmark nail destruction and preferential involvement of body extremities. Moreover, etiological therapy against underlying malignancy is essential for treating paraneoplastic B...Continue Reading

References

Sep 1, 1980·The British Journal of Dermatology·A Bazex, A Griffiths
May 18, 2005·Clinics in Dermatology·Stephen P Stone, Lucinda S Buescher
Nov 21, 2007·Dermatologic Clinics·Rachael L Moore, Theresa S Devere
Oct 8, 2008·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Guillaume LouvelJean-Luc Raoul
Oct 15, 2009·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Antonio CrucittiPierluigi Maria Granone
Nov 9, 2010·Dermatologic Therapy·Ana Maria Abreu Velez, Michael S Howard

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Citations

Mar 9, 2017·Journal of the European Academy of Dermatology and Venereology : JEADV·F RäßlerP Elsner

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Methods Mentioned

BETA
biopsy

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