Case Report: Behçet's disease accompanied with vitiligo

F1000Research
Ragıp ErtaşMustafa Atasoy

Abstract

Recently, a few case reports and clinical studies have been published that explore the association of Behçet's Disease (BD) and vitiligo, with conflicting results. Genetic and immunological properties of BD and presence of autoantibodies support autoimmunity, but clinical features suggest autoinflammatory diseases. BD is thought to be a cornerstone between autoimmune and autoinflammatory diseases. On the other hand, vitiligo has been accepted as an autoimmune disease with associations of other autoimmune disorders and there is a possible role of autoimmunity in pathogenesis of the disease. Significant advances have been made understanding the pathogenesis and genetics of BD. However, it is worth presenting rare clinical variants for improving the clinical understanding of BD. Herein, we are presenting a case with diagnosis of both Behçet's disease and vitiligo in same patient, which is a rare occurrence. Discussion and demonstrating the association of these two diseases may give rise to understanding similar and different aspects of autoimmunity and autoinflammatory pathogenesis of both diseases.

References

Nov 1, 1996·The British Journal of Ophthalmology·K Norose, A Yano
May 20, 1998·Journal of the American Academy of Dermatology·S O Kovacs
Oct 30, 2001·Autoimmunity·E H KempA P Weetman
Jun 6, 2009·American Journal of Clinical Dermatology·Yelda KarincaogluBirgul Tepe
Jun 25, 2009·Clinical and Experimental Dermatology·M BorluC Evereklioglu
Dec 27, 2011·Autoimmunity Reviews·Marc Pineton de ChambrunDavid Saadoun
Sep 7, 2012·Case Reports in Medicine·Esra GuneyHuseyin Bayramlar
Feb 28, 2013·Journal of the European Academy of Dermatology and Venereology : JEADV·UNKNOWN International Team for the Revision of the International Criteria for Behçet's Disease (ITR-ICBD)

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Citations

Sep 12, 2021·BMC Research Notes·Samuel J Shenoi, Erich J Baker

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