Case Report: Corneal Coinfection with Fungus and Amoeba : Report of Two Patients and Literature Review

The American Journal of Tropical Medicine and Hygiene
Joveeta JosephSavitri Sharma

Abstract

We report two cases of corneal coinfection with Acanthamoeba and Fusarium sp. along with the review of published literature. A 35-year-old woman and 65-year-old man presented to the institute with corneal ulcer refractory for treatment with topical antibiotics. Microbiological examination revealed the presence of Acanthamoeba cysts along with septate, hyaline fungal filaments. After emergency therapeutic penetrating keratoplasty (TPK) in both, the corneal tissue was sent for histopathologic examination, which confirmed the presence of Acanthamoeba and fungal coinfection. One patient had a recurrence of fungal infection after TPK. In subjects with a rapid progression of mycotic ulcer, coinfection with other microorganisms including Acanthamoeba should be suspected. The two cases presented here emphasize the importance of microbiology in making prompt diagnosis and appropriate management of these cases at an early stage.

References

Jun 1, 1995·American Journal of Ophthalmology·J R GusslerE C Alfonso
Sep 27, 2000·The British Journal of Ophthalmology·S SharmaG N Rao
Apr 9, 2001·American Journal of Ophthalmology·N A FroumisB J Glasgow
Apr 29, 2005·International Journal of Clinical Practice·H-C LinS-C Shen
May 9, 2008·Eye & Contact Lens·D Snow SladeGeoffrey Tabin
May 30, 2008·Acta Ophthalmologica·Hsin-Chiung LinSamuel Chao-Ming Huang
Dec 17, 2008·Investigative Ophthalmology & Visual Science·Jianzhang HuLixin Xie
Jan 12, 2010·Indian Journal of Medical Microbiology·N GuptaU Chaudhary
Feb 7, 2016·Acta Tropica·Thais Esther Teixeira NunesMarilise Brittes Rott

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Citations

Jan 24, 2019·Journal of Fungi·Arturo CasadevallPatricia Albuquerque
Mar 20, 2020·Infectious Disorders Drug Targets·Debarati PaulSanti M Mandal
Jan 8, 2022·Investigative Ophthalmology & Visual Science·Stephnie M KennedyRachel L Williams

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Antifungals (ASM)

An antifungal, also known as an antimycotic medication, is a pharmaceutical fungicide or fungistatic used to treat and prevent mycosis such as athlete's foot, ringworm, candidiasis, cryptococcal meningitis, and others. Discover the latest research on antifungals here.

Antifungals

An antifungal, also known as an antimycotic medication, is a pharmaceutical fungicide or fungistatic used to treat and prevent mycosis such as athlete's foot, ringworm, candidiasis, cryptococcal meningitis, and others. Discover the latest research on antifungals here.