Case Report: Effect of Antigravity Treadmill Training on Muscle Oxidative Capacity, Muscle Endurance, and Walking Function in a Person with Multiple Sclerosis

International Journal of MS Care
T Bradley WillinghamDeborah Backus

Abstract

Exercise training can improve skeletal muscle metabolism in persons with multiple sclerosis (MS). However, quantification of exercise-mediated improvements in muscle metabolism has been limited, particularly in people with high levels of disability. We evaluated the effect of 9 weeks of antigravity treadmill training on muscle oxidative capacity and muscle endurance and assessed the relationship to walking function in a person with MS. One person with MS (Expanded Disability Status Scale score, 6.5) performed treadmill training for 24 minutes approximately twice weekly for 9 weeks (16 sessions) using an antigravity treadmill system. Before and after the intervention phase, we measured muscle oxidative capacity in the medial gastrocnemius using near-infrared spectroscopy after 15 to 20 seconds of electrical stimulation; muscle endurance in the medial gastrocnemius using accelerometer-based mechanomyography during 9 minutes of twitch electrical stimulation in three stages (3 minutes per stage) of increasing frequency (2, 4, and 6 Hz); muscle strength (plantarflexion) using a maximal voluntary contraction; and walking function using the Timed 25-Foot Walk test and the 2-Minute Walk Test. Muscle oxidative capacity increased from 0....Continue Reading

References

Aug 1, 1994·Muscle & Nerve·J A Kent-BraunM W Weiner
Feb 1, 1997·The American Journal of Physiology·A T PaganiniR A Meyer
Feb 14, 1998·Journal of Applied Physiology·J A Kent-BraunR G Miller
Aug 20, 2002·Journal of Neurology, Neurosurgery, and Psychiatry·P Thoumie, E Mevellec
Oct 19, 2007·Multiple Sclerosis : Clinical and Laboratory Research·Myla D GoldmanJeffrey A Cohen
Oct 19, 2007·Multiple Sclerosis : Clinical and Laboratory Research·S BeerJ Kesselring
Dec 7, 2007·Journal of the Neurological Sciences·Robert W Motl, Erin M Snook
Oct 31, 2008·Neurorehabilitation and Neural Repair·Albert C Lo, Elizabeth W Triche
Mar 3, 2010·Multiple Sclerosis : Clinical and Laboratory Research·U DalgasT Ingemann-Hansen
Mar 9, 2010·Multiple Sclerosis : Clinical and Laboratory Research·Domien GijbelsPeter Feys
Mar 11, 2010·American Journal of Physical Medicine & Rehabilitation·Burcu Duyur CaktUfuk Ergün
Jun 7, 2011·Multiple Sclerosis : Clinical and Laboratory Research·D GijbelsP Feys
Jan 4, 2012·Acta Neurologica Scandinavica·B M SandroffR W Motl
Mar 1, 2012·The Journal of Neuroscience Nursing : Journal of the American Association of Neuroscience Nurses·Pamela K NewlandAndrew Neath
Mar 2, 2012·Physiotherapy Canada. Physiothérapie Canada·Jane L WetzelLucinda A Pfalzer
May 9, 2012·Multiple Sclerosis : Clinical and Laboratory Research·Tom BroekmansPeter Feys
Jul 3, 2013·Archives of Physical Medicine and Rehabilitation·Terence E RyanKevin K McCully
Aug 21, 2013·NeuroRehabilitation·Arzu Guclu-GunduzHale Zeynep Batur-Caglayan
Sep 24, 2013·Multiple Sclerosis : Clinical and Laboratory Research·A G SkjerbækU Dalgas
Jul 18, 2015·International Journal of Molecular Sciences·Arno KerlingAnja Windhagen
Feb 27, 2016·International Journal of MS Care·Afshin SamaeiFatemeh Motaharinezhad
Dec 22, 2016·Muscle & Nerve·Hannah M BossieKevin K McCully
Jan 21, 2017·Multiple Sclerosis and Related Disorders·Yunju LeeLi-Qun Zhang
Jun 14, 2017·Multiple Sclerosis Journal - Experimental, Translational and Clinical·Mary Ann HarpDeborah Backus

❮ Previous
Next ❯

Citations

Jan 5, 2021·Biomedical Engineering Online·Raphael UwamahoroIndra Devi Subramaniam
Jan 27, 2019·Journal of Functional Morphology and Kinesiology·Kevin K McCullyT Bradley Willingham
Oct 2, 2019·Journal of Stroke and Cerebrovascular Diseases : the Official Journal of National Stroke Association·Lu LuoSong Yuan

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Multiple Sclerosis : Clinical and Laboratory Research
Lesley J WhiteK Vandenborne
International Journal of Rehabilitation Research. Internationale Zeitschrift Für Rehabilitationsforschung. Revue Internationale De Recherches De Réadaptation
Mark M MañagoMargaret Schenkman
© 2022 Meta ULC. All rights reserved