Jan 27, 2018

Case report: mechanisms of HIV elite control in two African women

BMC Infectious Diseases
Yumna MoosaWendy A Burgers

Abstract

The majority of people living with HIV require antiretroviral therapy (ART) for controlling viral replication, however there are rare HIV controllers who spontaneously and durably control HIV in the absence of treatment. Understanding what mediates viral control in these individuals has provided us with insights into the immune mechanisms that may be important to induce for a vaccine or functional cure for HIV. To date, few African elite controllers from high incidence settings have been described. We identified virological controllers from the CAPRISA 002 cohort of HIV-1 subtype C infected women in KwaZulu Natal, South Africa, two (1%) of whom were elite controllers. We examined the genetic, clinical, immunological and virological characteristics of these two elite HIV controllers in detail, to determine whether they exhibit features of putative viral control similar to those described for elite controllers reported in the literature. In this case report, we present clinical features, CD4+T cell and viral load trajectories for two African women over 7 years of HIV infection. Viral load became undetectable 10 months after HIV infection in Elite Controller 1 (EC1), and after 6 weeks in Elite Controller 2 (EC2), and remained unde...Continue Reading

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References

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Mentioned in this Paper

Flow Cytometry
T-Lymphocyte
Virus
Follow-up
HLA-DRB1*13 antigen
Oncoprotein p21
Vaccines
Virus Replication
HLA-B gene
Human Leukocyte Antigen DRB1 (Lab Test)