Case Report of Acquired Generalized Lipodystrophy Associated With Common Variable Immunodeficiency

The Journal of Clinical Endocrinology and Metabolism
Bruno HalpernMaria Adelaide Albergaria Pereira

Abstract

Acquired generalized lipodystrophy (AGL), a rare disorder characterized by loss of subcutaneous adipose tissue, is estimated to occur in association with autoimmune diseases in ~25% of the cases. Common variable immunodeficiency (CVI) is a condition known for its strong association with autoimmune diseases often occurring with negative autoantibodies. To the best of our knowledge, we describe the first known case of AGL in a patient with CVI. A 24-year-old man was referred to our center with hyperglycemia, hypertriglyceridemia, hepatomegaly, and a clear pattern of generalized fat loss. AGL had been diagnosed on the basis of the clinical and laboratory findings. Because of the presence of associated hypogammaglobulinemia, a diagnosis of CVI was subsequently established. We propose that AGL be added to the list of possible diseases associated with CVI and, owing to the similar clinical presentation with type 1 diabetes mellitus, be included in the differential diagnosis of this condition, which is present in 1.5% of patients with CVI.

References

Oct 16, 2008·The Journal of Clinical Endocrinology and Metabolism·David B SavageStephen O'Rahilly
Aug 13, 2009·Current Allergy and Asthma Reports·Shradha Agarwal, Charlotte Cunningham-Rundles
Aug 26, 2011·The Journal of Clinical Endocrinology and Metabolism·Abhimanyu Garg
Oct 3, 2012·Current Opinion in Allergy and Clinical Immunology·Elena S Resnick, Charlotte Cunningham-Rundles
Jun 5, 2013·Expert Review of Clinical Immunology·Hassan AbolhassaniAsghar Aghamohammadi
Jun 10, 2015·JAMA : the Journal of the American Medical Association·Mary E Rinella
Sep 22, 2015·The Journal of Clinical Endocrinology and Metabolism·Jasmin LebastchiElif A Oral
Jan 23, 2016·International Archives of Allergy and Immunology·Tomáš MilotaUNKNOWN ESID Registry Working Party

❮ Previous
Next ❯

Citations

May 6, 2020·Expert Review of Endocrinology & Metabolism·Maria C Foss-FreitasElif A Oral
Jan 27, 2020·Annales d'endocrinologie·Camille SollierCorinne Vigouroux

❮ Previous
Next ❯

Related Concepts

Related Feeds

Autoimmune Diseases

Autoimmune diseases occur as a result of an attack by the immune system on the body’s own tissues resulting in damage and dysfunction. There are different types of autoimmune diseases, in which there is a complex and unknown interaction between genetics and the environment. Discover the latest research on autoimmune diseases here.

© 2022 Meta ULC. All rights reserved