Case report of acute vitamin D intoxication in an infant

Srpski arhiv za celokupno lekarstvo
Nedeljko RadlovićBiljana Vuletić

Abstract

Vitamin D intoxication represents a rare and potentially serious pathological condition caused by the excess of calcium and phosphorus. We are presenting an infant with vitamin D intoxication due to excessive daily administration, as well as therapeutic procedures that prevented its adverse effects. A 1.5-month-old female infant, born at term, exclusively breastfed and without any complaints and abnormalities of physical findings, was observed due to the data that during the preceding month, by her mother's mistake, she had received about 200,000 IU of vitamin D3. Laboratory analyses showed a high serum level of 25(OH)D (>400 nmol/L) and calcium (2.72 mmol/L), lowered PTH (6.6 pg/ml) and high urinary calcium/creatinine ratio (1.6), while other findings, including urotract ultrasonography image, were within normal limits. Treatment based on the discontinuation of vitamin D administration, infant's forced water intake, as well as the application of 2-month prednisolone and 4-month phenobarbitone and furosemide, resulted in complete normalization of the laboratory indicators of vitamin D overdose, as well as the prevention of its adverse effects. By timely recognition and adequate treatment, including triple therapy with prednisol...Continue Reading

Citations

Jul 21, 2020·BMC Pediatrics·Fariba FarnaghiMaryam Hosseini Yazdi
Sep 29, 2017·Global Pediatric Health·Nordie A Bilbao
Aug 7, 2018·EFSA Journal·UNKNOWN EFSA Panel on Dietetic Products, Nutrition and Allergies (EFSA NDA Panel)Monika Neuhäuser-Berthold
Jul 13, 2021·Child Neurology Open·Naik TriptyJondhale Sunil

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