Case Report of Menopausal Woman Diagnosed with Endometrial Cancer after Colon Cancer with Germline Mutation in MSH6 in Korea

Journal of Menopausal Medicine
Hyun Jung LeeJa-Hyun Jang

Abstract

We present a case of an endometrial cancer patient with germline mutation in MutS homolog 6 (MSH6), associated with Lynch syndrome. A 60-year-old Korean woman had a personal history of colon cancer 23 years ago. She also had a family history of endometrial cancer and colon cancer of her sisters and brothers. Immunohistochemistry was negative for MutL homolog 1 (MLH1) and positive for MutS homolog 2 (MSH2). Based on these findings, she underwent genetic counseling and testing that revealed a frameshift germline mutation at MSH6 (c. 3261dupC).

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Citations

Feb 15, 2018·The Journal of Obstetrics and Gynaecology Research·Hyun J LeeJe H Lee

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Methods Mentioned

BETA
hysterectomy
biopsy

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