Case report of restoration of the corneal epithelium in a patient with atopic keratoconjunctivitis resulting in amelioration of ocular allergic inflammation

Allergology International : Official Journal of the Japanese Society of Allergology
Ken FukudaTeruo Nishida

Abstract

Atopic and vernal keratoconjunctivitis are severe types of ocular allergic disease characterized not only by conjunctival inflammation but also by corneal involvement. In vitro studies have suggested that breakdown of corneal epithelial barrier function and subsequent activation of stromal fibroblasts may amplify ocular allergic inflammation. A 27-year-old man with atopic dermatitis developed atopic keratoconjunctivitis including corneal ulcer with plaque deposition in his right eye. Conjunctival inflammation in the right eye was resistant to topical steroid therapy. Surgical removal of corneal plaque and administration of autologous fibronectin eyedrops resulted not only in resurfacing of the corneal epithelium but also in amelioration of conjunctival inflammation. This case suggests that loss of corneal epithelial integrity likely exacerbates conjunctival allergic inflammation and that restoration or maintenance of the barrier function of the corneal epithelium may be one of the important targets for the treatment of severe ocular allergic diseases.

References

Nov 1, 1983·The Journal of Cell Biology·T NishidaR Manabe
Jul 1, 1983·Archives of Ophthalmology·T NishidaR Manabe
Oct 18, 2000·Japanese Journal of Ophthalmology·H FujishimaK Tsubota
Jan 24, 2006·Progress in Retinal and Eye Research·Naoki KumagaiTeruo Nishida
Nov 1, 2006·Allergology International : Official Journal of the Japanese Society of Allergology·Ken FukudaTeruo Nishida
May 16, 2009·Journal of Ocular Pharmacology and Therapeutics : the Official Journal of the Association for Ocular Pharmacology and Therapeutics·Nobuyuki EbiharaHiroshi Fujishima
Aug 25, 2009·Allergology International : Official Journal of the Japanese Society of Allergology·Kazumi FukagawaHirohisa Saito
Feb 18, 2010·The Journal of Allergy and Clinical Immunology·Ken Fukuda, Teruo Nishida

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Citations

Apr 1, 2014·Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology·Leonard Bielory
Apr 20, 2011·Allergology International : Official Journal of the Japanese Society of Allergology·Ken FukudaAtsuki Fukushima
Jun 13, 2014·American Journal of Physiology. Cell Physiology·Lila G GlotfeltyGail A Hecht
Jun 18, 2020·Journal of Medical Case Reports·Ricardo Alexandre StockElcio Luiz Bonamigo
Sep 14, 2020·Experimental Eye Research·Ken Fukuda

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