Case Report: Rapid Eye Movement Sleep Behavior Disorder as the First Manifestation of Multiple Sclerosis: A Case Report and Literature Review

International Journal of MS Care
Alejandro Enriquez-MarulandaJairo Quiñones

Abstract

Rapid eye movement sleep behavior disorder (RBD) is a parasomnia characterized by brief recurrent episodes of loss of muscle atonia during rapid eye movement sleep, with enacted dreams that cause sleep disruption. Patients with multiple sclerosis (MS) have an increased risk compared with the general population to be affected by a sleep disturbance, including RBD. Patients affected, however, uncommonly can present RBD as the first clinical manifestation of MS without other neurologic deficits. These clinical presentations have usually been attributed to inflammatory lesions in the pedunculopontine nuclei, located in the dorsal pons. We present a case of RBD in a 38-year-old woman who was later diagnosed as having MS due to imaging findings and development of focal neurologic deficits. MS should be considered among the differential diagnoses in patients who present with symptoms of RBD, particularly if they are young and female.

References

Sep 28, 2000·The New England Journal of Medicine·J H NoseworthyB G Weinshenker
Nov 1, 2003·Sleep Medicine·Giuseppe Plazzi, Pasquale Montagna
Mar 31, 2005·Seminars in Neurology·W Elon Fleming, Charles P Pollak
Apr 26, 2006·Neurology·Maja Tippmann-PeikertB Mark Keegan
Apr 7, 2007·Brain : a Journal of Neurology·B F BoeveH Braak
Jul 7, 2007·Multiple Sclerosis : Clinical and Laboratory Research·M J Gómez-ChocoA Saiz
Jul 18, 2008·Multiple Sclerosis : Clinical and Laboratory Research·A M BamerG H Kraft
Oct 31, 2008·Lancet·Alastair Compston, Alasdair Coles
Nov 3, 2009·Sleep Medicine Reviews·Steven D BrassSanford Auerbach
May 11, 2010·The Medical Clinics of North America·Eric Frenette
Aug 5, 2011·Journal of the Neurological Sciences·Ana Caminero, Manuel Bartolomé
May 26, 2012·European Neurology·Jean-Philippe NeauGautier Bouche
Oct 27, 2012·Neurologic Clinics·Charlene E GamaldoJustin C McArthur
Oct 31, 2012·Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology·Anna Pokryszko-DraganKatarzyna Konieczna
Dec 5, 2012·Acta Neurologica Scandinavica. Supplementum·H M B LundeL Bø
Mar 29, 2014·Trends in Neurosciences·John PeeverJacques Montplaisir
Aug 2, 2014·Journal of Clinical Neurophysiology : Official Publication of the American Electroencephalographic Society·Jian-Hua ChenYan Huang
Dec 24, 2014·Multiple Sclerosis : Clinical and Laboratory Research·Ruth Ann MarrieOlaf Stuve
Mar 6, 2015·Clinical Autonomic Research : Official Journal of the Clinical Autonomic Research Society·Jose-Alberto PalmaHoracio Kaufmann
Apr 14, 2015·JAMA Neurology·Michael Joseph Howell, Carlos Hugh Schenck
Aug 8, 2015·Nature Reviews. Immunology·Calliope A DendrouManuel A Friese
Nov 26, 2015·Therapeutic Advances in Neurological Disorders·Tiffany J Braley, Ronald D Chervin

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Citations

Jul 16, 2019·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Alex Iranzo
Aug 7, 2020·Continuum : Lifelong Learning in Neurology·Joseph S Kass, Rachel V Rose

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