Case report: severe cytomegalovirus primary infection in an immunocompetent adult with disseminated intravascular coagulation treated with valganciclovir

BMC Infectious Diseases
Niklas F MüllerKlaus Hamprecht

Abstract

Disseminated intravascular coagulation (DIC) is a very rare complication of disseminated cytomegalovirus (CMV) infection. So far it is mainly described for immunocompromised patients. A 49-year-old immunocompetent Caucasian male presented with sudden onset of fever and DIC due to primary CMV infection, which was treated with Valganciclovir. CMV-specific IgG-avidity and epithelial cell-specific neutralisation-capacity developed five weeks after onset of symptoms. We describe the first case of an immunocompetent patient suffering from DIC due to a CMV primary infection successfully treated with Valganciclovir. Primary CMV infection can occur accompanied with life threatening complications even in immunocompetent patients. Immediate treatment with Valganciclovir should be considered as an early treatment of choice in severe cases since specific neutralisation capacity might need several weeks to develop.

References

Sep 26, 2001·Archives of Internal Medicine·S HumblotA S Korganow
Nov 19, 2011·Journal of Medical Virology·Michelle L M PoonYen Lin Chee
Jan 1, 2011·BMJ Case Reports·Susan E Snape, Pradhib Venkatesan
Sep 15, 2012·Journal of Clinical Virology : the Official Publication of the Pan American Society for Clinical Virology·Elisabetta GrilliNicola Petrosillo
Mar 8, 2013·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·R R RazonableUNKNOWN AST Infectious Diseases Community of Practice
Feb 22, 2014·Arteriosclerosis, Thrombosis, and Vascular Biology·Alice AssingerCecilia Söderberg-Naucler
Mar 19, 2014·Methods in Molecular Biology·Maciej T NogalskiAndrew D Yurochko
Apr 20, 2014·Journal of Clinical Virology : the Official Publication of the Pan American Society for Clinical Virology·Klaus HamprechtGerhard Jahn
Apr 23, 2014·Journal of Infection and Chemotherapy : Official Journal of the Japan Society of Chemotherapy·Daiki KariganeTakehiko Mori

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Citations

Apr 16, 2020·Journal of Thrombosis and Haemostasis : JTH·Francesco MarongiuDoris Barcellona
Jul 29, 2021·The New England Journal of Medicine·Olivia C SmibertMatthew B Roberts
Aug 24, 2021·Case Reports in Infectious Diseases·Helena LuísNancy Faria

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Methods Mentioned

BETA
X-ray
PCR

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