Case selection in minimally invasive surgical treatment of neuroblastoma.

Pediatric Surgery International
John BoutrosErik D Skarsgard

Abstract

The experience with minimally invasive surgery (MIS) in the treatment of neuroblastoma (NB) is anecdotal. The purpose of this study was to evaluate a retrospective cohort of NB patients who underwent MIS resection of their primary tumors. A retrospective study of NB patients who underwent MIS resection of their primary tumors over a 3-year period was undertaken. Study outcomes included complications, completeness of resection, and event-free and overall short-term survival. Of a total of 21 children who underwent surgical resection for NB during the period of study, 8 (38%) underwent selected MIS resection. Six of the eight (75%) tumors were adrenal in origin and the remainder were located in the posterior mediastinum. Distribution by International Neuroblastoma Staging System (INSS) stage was: stage 1 (3), stage 2 (2), and stage 4 (3). One stage 4 tumor was N-myc amplified. All stage 4 patients experienced a >50% tumor volume cytoreduction in response to preoperative chemotherapy. All MIS resections were performed without need for blood transfusion, or conversion to open procedure, and there were no perioperative complications. All eight patients were alive and disease-free at a median 18-month follow-up. With appropriate preo...Continue Reading

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Citations

Apr 22, 2009·Current Opinion in Pediatrics·Kanika A Bowen, Dai H Chung
Oct 8, 2014·Journal of Laparoendoscopic & Advanced Surgical Techniques. Part a·Alpin D MalkanJohn A Sandoval
Feb 23, 2010·Current Problems in Cancer·Natia EsiashviliHoward M Katzenstein
Jun 24, 2014·Journal of Pediatric Surgery·Alpin D MalkanJohn A Sandoval
Jul 28, 2016·Pediatric Surgery International·Yujiro TanakaHiroo Uchida
Mar 13, 2021·Surgical Oncology Clinics of North America·Marc W H Wijnen, Andrew M Davidoff
Jun 3, 2021·Children·Federica FatiGiuseppe Martucciello

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