Abstract
This study was designed to test the power potential of a number of different clinical trial designs that could be deployed to test the efficacy of an antimuscarinic drug against bladder retraining. This was an observational cohort study. Data were collected prospectively from patients treated for an overactive bladder by antimuscarinic agents with bladder retraining, or by bladder retraining alone. At initiation and at followup data on frequency, incontinence, urgency and urge incontinence were collected. Data from visits up to 16 weeks of treatment were analyzed using the parametric methods.708 patients were studied, 44 males and 664 females, and their mean age was 54 (sd 22). 52 patients used pure bladder retraining and 656 used bladder retraining and an antimuscarinic agent. The drug was oxybutynin, tolterodine or imipramine combined with oxybutynin or tolterodine as combination therapy. A between groups analysis demonstrated that bladder retraining was associated with a greater improvement in urinary frequency compared to antimuscarinic therapy (Z = -4.6, 95% CI of difference -3.3, -1.4, p <0.001) whereas antimuscarinic therapy was associated with a greater improvement in incontinence compared to bladder retraining (Z = -2....Continue Reading
References
Aug 1, 1976·British Journal of Urology·D J Farrar, J L Osborne
Apr 27, 1991·BMJ : British Medical Journal·P A WisemanG S Rai
Dec 17, 1998·Journal of Neurology, Neurosurgery, and Psychiatry·C DeaneyJ G Malone-Lee
Dec 24, 1998·JAMA : the Journal of the American Medical Association·K L BurgioD Candib
Apr 21, 1999·The Journal of Urology·R MillardB E Davis
Jun 22, 2000·The New England Journal of Medicine·K Benson, A J Hartz
Jun 22, 2000·The New England Journal of Medicine·J ConcatoR I Horwitz
Apr 27, 2001·Mayo Clinic Proceedings·R A AppellUNKNOWN Overactive Bladder: Judging Effective Control and Treatment Study Group
Dec 31, 2002·Pediatric Annals·Stephen Ira Pelton
Nov 18, 2003·BJU International·Y HommaUNKNOWN Japanese and Korean Tolterodine Study Group
Feb 7, 2004·BJU International·C R ChappleUNKNOWN YM-905 Study Group
Mar 26, 2004·European Urology·F HaabP Dwyer
May 6, 2004·The Journal of Urology·Norman ZinnerUNKNOWN Trospium Study Group
Nov 16, 2004·The Journal of Urology·L CardozoA M Ridder
Mar 11, 2005·The Journal of Urology·J OstaszkiewiczB Roe
Citations
Jul 26, 2008·International Urogynecology Journal and Pelvic Floor Dysfunction·Mel LautiDon Wilson
Jan 22, 2008·The Journal of Urology·Salah Al-BuheissiJames Malone-Lee
Jun 15, 2007·Current Opinion in Urology