Case series data to encourage randomized trials of bladder retraining compared to antimuscarinic agents

The Journal of Urology
M GheiJ Malone-Lee

Abstract

This study was designed to test the power potential of a number of different clinical trial designs that could be deployed to test the efficacy of an antimuscarinic drug against bladder retraining. This was an observational cohort study. Data were collected prospectively from patients treated for an overactive bladder by antimuscarinic agents with bladder retraining, or by bladder retraining alone. At initiation and at followup data on frequency, incontinence, urgency and urge incontinence were collected. Data from visits up to 16 weeks of treatment were analyzed using the parametric methods.708 patients were studied, 44 males and 664 females, and their mean age was 54 (sd 22). 52 patients used pure bladder retraining and 656 used bladder retraining and an antimuscarinic agent. The drug was oxybutynin, tolterodine or imipramine combined with oxybutynin or tolterodine as combination therapy. A between groups analysis demonstrated that bladder retraining was associated with a greater improvement in urinary frequency compared to antimuscarinic therapy (Z = -4.6, 95% CI of difference -3.3, -1.4, p <0.001) whereas antimuscarinic therapy was associated with a greater improvement in incontinence compared to bladder retraining (Z = -2....Continue Reading

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Citations

Jul 26, 2008·International Urogynecology Journal and Pelvic Floor Dysfunction·Mel LautiDon Wilson
Jan 22, 2008·The Journal of Urology·Salah Al-BuheissiJames Malone-Lee
Jun 15, 2007·Current Opinion in Urology

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