Case series: neuropsychiatric symptoms with pediatric systemic lupus erythematosus

Journal of the American Academy of Child and Adolescent Psychiatry
S B TurkelA Reiff

Abstract

To describe the psychiatric presentation, serologic findings, and neuroimaging patterns in children and adolescents with central nervous system involvement with systemic lupus erythematosus (CNS-SLE). Pediatric patients with psychiatric symptoms who fulfilled the 1997 revised diagnostic American College of Rheumatology criteria for SLE were studied. Complement levels, and anti-double-stranded DNA, anti-Smith, anti-phospholipid, and anti-neuronal antibodies were evaluated. Computed tomography, magnetic resonance imaging, and single photon emission computed tomography (SPECT) neuroimaging studies were reviewed. The 10 patients with CNS-SLE presented with psychosis, mood disturbance, or confusion, and 8 patients had concomitant neurologic symptoms. The 8 girls and 2 boys ranged in age from 7.5 to 17 years. Serum anti-neuronal antibodies were positive with onset of symptoms and declined with improvement. Initial SPECT was abnormal in all 10 patients and remained abnormal. SPECT and anti-neuronal antibodies help confirm CNS involvement in patients with SLE and neuropsychiatric symptoms.

References

Jul 1, 1985·Arthritis and Rheumatism·A HowJ A Denburg
Nov 1, 1982·Arthritis and Rheumatism·E M TanR J Winchester
Nov 1, 1981·Arthritis and Rheumatism·C L YanceyB H Athreya
Jan 1, 1994·Springer Seminars in Immunopathology·A M Rosenberg
Oct 1, 1995·Pediatric Neurology·M I SteinlinE D Silverman
Oct 1, 1995·Pediatric Neurology·S ParikhY Kim
Oct 19, 1999·Arthritis and Rheumatism·W L SibbittW M Brooks

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Citations

Aug 18, 2004·Current Opinion in Rheumatology·Dorothee StichwehVirginia Pascual
Sep 20, 2005·The Australian and New Zealand Journal of Psychiatry·Mark WalterfangChristos Pantelis
Apr 1, 2014·Revista colombiana de psiquiatría·Yenny Carolina Zuñiga Zambrano, Rafael Vásquez
Aug 17, 2005·South African Medical Journal = Suid-Afrikaanse Tydskrif Vir Geneeskunde·G FallerD Hahn
Aug 28, 2014·Pediatric Neurology·Yenny Carolina Zuniga ZambranoAlvaro Hernando Izquierdo Bello
Jul 20, 2002·Current Rheumatology Reports·David Hermosillo-Romo, Robin L Brey
Aug 22, 2013·Current Psychiatry Reports·Brenda Bursch, Marcy Forgey
Mar 22, 2003·Journal of the American Academy of Child and Adolescent Psychiatry·Didier PerisseJean-Charles Piette
Mar 24, 2010·Journal of Psychosomatic Research·Sean Hatherill, Alan J Flisher
Jun 27, 2015·Pediatric Annals·Arzu Soybilgic
Oct 17, 2007·The Psychiatric Clinics of North America·Susan Turkel, Maryland Pao
Oct 17, 2002·Rheumatic Diseases Clinics of North America·Michael L Miller
Mar 21, 2009·Journal of Child Neurology·Sean Hatherill, Alan Flisher
Aug 23, 2007·Lupus·S M Benseler, E D Silverman
Dec 18, 2012·The Journal of Rheumatology·Lily Siok Hoon LimEarl D Silverman
Sep 22, 2011·Current Protocols in Pharmacology·Matthew M SeaveyKristine L Stump
Jul 14, 2018·Neurology Research International·Mohammad-Amin KhajezadehVahid Ziaee
Oct 17, 2002·Rheumatic Diseases Clinics of North America·Marisa Klein-GitelmanEarl D Silverman

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