Case Series of Severe Neurologic Sequelae of Ebola Virus Disease during Epidemic, Sierra Leone.

Emerging Infectious Diseases
Patrick HowlettJanet T Scott

Abstract

We describe a case series of 35 Ebola virus disease (EVD) survivors during the epidemic in West Africa who had neurologic and accompanying psychiatric sequelae. Survivors meeting neurologic criteria were invited from a cohort of 361 EVD survivors to attend a preliminary clinic. Those whose severe neurologic features were documented in the preliminary clinic were referred for specialist neurologic evaluation, ophthalmologic examination, and psychiatric assessment. Of 35 survivors with neurologic sequelae, 13 had migraine headache, 2 stroke, 2 peripheral sensory neuropathy, and 2 peripheral nerve lesions. Of brain computed tomography scans of 17 patients, 3 showed cerebral and/or cerebellar atrophy and 2 confirmed strokes. Sixteen patients required mental health followup; psychiatric disorders were diagnosed in 5. The 10 patients who experienced greatest disability had co-existing physical and mental health conditions. EVD survivors may have ongoing central and peripheral nervous system disorders, including previously unrecognized migraine headaches and stroke.

References

Dec 6, 2007·The Journal of Infectious Diseases·Thomas LarsenThomas W Geisbert
Apr 17, 2014·Headache·Shivang G Joshi, Tracey A Cho
Mar 3, 2015·The American Journal of Psychiatry·Abdulaziz MohammedAkin Oyemakinde
Apr 26, 2015·The Lancet Infectious Diseases·Danielle V ClarkMerlin L Robb
Jun 11, 2015·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Adnan I QureshiKezely Beavogui
Jul 23, 2015·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Emmanuel SaguiThierry Carmoi
Sep 10, 2015·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Margaret NanyongaDaniel G Bausch
Nov 28, 2015·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Andrew J WilsonMichael Jacobs
Dec 18, 2015·The New England Journal of Medicine·Lauren EpsteinTimothy M Uyeki
Dec 23, 2015·Emerging Infectious Diseases·Patrick HowlettMarta Lado
Mar 1, 2016·Neuropharmacology·Nicholas H HuntHelen J Ball
Mar 18, 2016·Emerging Infectious Diseases·Janet T ScottMalcolm G Semple
Mar 30, 2016·The Lancet Infectious Diseases·Pauline VetterDaniel G Bausch
Apr 5, 2016·Annals of Internal Medicine·Daniel S ChertowRichard T Davey
May 23, 2016·Lancet·Michael JacobsEmma C Thomson
Jul 15, 2016·Neurotherapeutics : the Journal of the American Society for Experimental NeuroTherapeutics·Bridgette Jeanne BilliouxAvindra Nath
Jul 16, 2016·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Thierry de GreslanGilles Cellarier
Jul 21, 2016·Journal of Neurology, Neurosurgery, and Psychiatry·Emanuele NicastriUNKNOWN INMI's Ebola Team
Jan 18, 2017·The Lancet Infectious Diseases·Jean-François EtardUNKNOWN Postebogui Study Group
Jun 20, 2017·Emerging Infectious Diseases·Paul J SteptoeMalcolm G Semple
Oct 12, 2017·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Soushieta JagadeshJanet T Scott

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Citations

Jul 25, 2019·The American Journal of Tropical Medicine and Hygiene·Samuel C FicenecSusan D Emmett
Jan 1, 2019·Expert Review of Ophthalmology·Duncan E BerryJessica G Shantha
Jul 15, 2020·Nature Reviews. Neurology·Prashanth S Ramachandran, Michael R Wilson
Jun 17, 2020·Social Psychiatry and Psychiatric Epidemiology·Jude Mary CénatOléa Makila-Balayulu
Jan 15, 2021·The Lancet. Respiratory Medicine·Nathan PraschanZeina Chemali
Dec 7, 2019·Journal of Autoimmunity·Manuel RojasJuan-Manuel Anaya
Jan 26, 2021·Journal of the Neurological Sciences·Olukemi AdekanmbiSulaiman Lakoh
Mar 17, 2021·The International Journal of Social Psychiatry·Zhifeng Wang, Dongmei Wang
Feb 20, 2019·Lancet·Denis MalvyJohan van Griensven

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Methods Mentioned

BETA
PCR

Software Mentioned

Mango
Excel
Stata

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