Case Study: Intra-Patient Heterogeneity of Aneurysmal Tissue Properties

Frontiers in Cardiovascular Medicine
Giampaolo MartufiElena S Di Martino

Abstract

Introduction: Current recommendations for surgical treatment of abdominal aortic aneurysms (AAAs) rely on the assessment of aortic diameter as a marker for risk of rupture. The use of aortic size alone may overlook the role that vessel heterogeneity plays in aneurysmal progression and rupture risk. The aim of the current study was to investigate intra-patient heterogeneity of mechanical and fluid mechanical stresses on the aortic wall and wall tissue histopathology from tissue collected at the time of surgical repair. Methods: Finite element analysis (FEA) and computational fluid dynamics (CFD) simulations were used to predict the mechanical wall stress and the wall shear stress fields for a non-ruptured aneurysm 2 weeks prior to scheduled surgery. During open repair surgery one specimen partitioned into different regions was collected from the patient's diseased aorta according to a pre-operative map. Histological analysis and mechanical testing were performed on the aortic samples and the results were compared with the predicted stresses. Results: The preoperative simulations highlighted the presence of altered local hemodynamics particularly at the proximal segment of the left anterior area of the aneurysm. Results from the ...Continue Reading

References

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Citations

Apr 24, 2020·Journal of Vascular Surgery Cases and Innovative Techniques·Arianna FornerisElena S Di Martino

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Software Mentioned

ScanIP
FEAP
VASCOPS
MATLAB
Fluent
ScanFE

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