Case study: the use of melatonin in a boy with refractory bipolar disorder

Journal of the American Academy of Child and Adolescent Psychiatry
J M Robertson, P E Tanguay

Abstract

The authors describe the clinical course of a 10-year-old boy with bipolar disorder diagnosed at age 5 years. Lithium, carbamazepine, and valproic acid were ineffective or caused intolerable side effects. A trial of melatonin led to rapid relief of insomnia and aborted a manic episode. He has continued to take melatonin and adjunctive alprazolam for 15 months without recurrence of insomnia or mania. Affective disorders involving circadian dysregulation may respond to interventions that restore a normal sleep-wake cycle. Literature supporting this hypothesis is cited.

References

Aug 1, 1990·Psychiatry Research·R W LamJ C Gillin
Sep 1, 1985·The American Journal of Psychiatry·L J Siever, K L Davis
Feb 15, 1988·Biological Psychiatry·A Miles, D R Philbrick
May 1, 1987·Journal of the American Academy of Child and Adolescent Psychiatry·A CavalloW J Meyer
Feb 1, 1987·The American Journal of Psychiatry·T A WehrN E Rosenthal
Apr 26, 1980·Lancet·D PickarW E Bunney
Jul 28, 1995·Psychiatry Research·A ValevskiA Weizman
Mar 1, 1995·Clinical Endocrinology·S M Webb, M Puig-Domingo
Jun 1, 1979·Journal of Youth and Adolescence·D Preodor, E A Wolpert

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Citations

Dec 21, 2000·Current Psychiatry Reports·G A Carlson, S E Meyer
Jun 14, 2003·Journal of Child and Adolescent Psychopharmacology·E Juulia PaavonenLennart von Wendt
Jun 2, 2001·Journal of Clinical Psychopharmacology·G KatzH Y Knobler
Jun 1, 2006·Acta Neuropsychiatrica·Karen T HallamPatrick D McGorry
May 4, 2006·Journal of the American Academy of Child and Adolescent Psychiatry·Margaret D WeissRoger D Freeman
Mar 7, 2009·Child and Adolescent Psychiatric Clinics of North America·Mona PotterJanet Wozniak
Jun 25, 2009·Human Psychopharmacology·Maria D MaldonadoMaria A Pérez-San-Gregorio
May 5, 2001·Expert Opinion on Pharmacotherapy·K D Chang, T A Ketter
Mar 3, 2015·Expert Opinion on Therapeutic Targets·Frank BellivierJan Scott
Jan 27, 2006·The Cochrane Database of Systematic Reviews·S L JansenD G Morgan
Oct 3, 2018·American Journal of Therapeutics·Ahmed NaguyTarek Shoukry

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Bipolar disorder is characterized by manic and/or depressive episodes and associated with uncommon shifts in mood, activity levels, and energy. Discover the latest research this illness here.

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