Cases of ergotism in livestock and associated ergot alkaloid concentrations in feed

Frontiers in Chemistry
A Morrie CraigJennifer M Duringer

Abstract

Ergot-induced disease in humans was known long before Biblical times and has been the root cause for countless human epidemics spanning from the early fourteenth century to the late sixteenth century. In contrast, many of these same ergot alkaloids have been utilized for their medicinal properties to mitigate migraine headaches and have had indications as anti-carcinogens. Although ergot alkaloids have been used for centuries by humans, basic pharmacokinetic data has not been documented for clinical disease in livestock. Consequently, a threshold dose and accurate dose-response data have yet to be established. Throughout the past several years, new detection techniques have emerged to detect these alkaloids at the parts per billion (ppb) level which has allowed for new efforts to be made with respect to determining threshold levels and making accurate clinical diagnoses in affected animals. This perspectives article provides a critical initial step for establishing a uniform interpretation of ergot toxicosis from limited existing data.

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Citations

Apr 11, 2015·Frontiers in Chemistry·James L Klotz, Darrin L Smith
Mar 13, 2018·Journal of Animal Science·Douglas M Liebe, Robin R White
May 28, 2019·Applied and Environmental Microbiology·Ryan S MoteNikolay M Filipov
May 10, 2020·Applied and Environmental Microbiology·Caroline E LeadmonDaniel G Panaccione
Nov 6, 2018·Frontiers in Veterinary Science·Vanessa Elizabeth CowanJaswant Singh
Feb 21, 2021·Journal of the Science of Food and Agriculture·Natalia Arroyo-ManzanaresLaura Gámiz-Gracia
Apr 22, 2017·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Ryan S MoteNikolay M Filipov
May 1, 2021·Toxins·Rossalin YonpiamAhmad Al-Dissi

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