CASP7 variants modify susceptibility to cervical cancer in Chinese women

Scientific Reports
Ting-Yan ShiQingyi Wei

Abstract

Polymorphisms in Caspase-7 (CASP7) may modulate the programmed cell death and thus contribute to cervical cancer risk. In this case-control study of 1,486 cervical cancer cases and 1,301 controls, we investigated associations between four potentially functional polymorphisms in CASP7 and cervical cancer risk and evaluated their locus-locus interaction effects on the risk. The genotype-phenotype correlation was performed by a generalized linear regression model. We found that the rs4353229 polymorphism was associated with cervical cancer risk (under a recessive model: crude OR = 1.20, 95% CI = 1.02-1.40). Compared with the TT genotype, the rs10787498GT genotype was associated with an increased cervical cancer risk (adjusted OR = 1.19, 95% CI = 1.00-1.41). Combination analysis showed that subjects with four putative risk genotypes had a 1.54-fold increased cancer risk, compared with those who carried three or less putative risk genotypes. We also observed significant locus-locus joint effects on the risk, which may be mediated by the polymorphisms regulating CASP7 mRNA expression. Subsequent multifactor dimensionality reduction and classification and regression tree analyses indicated that the CASP7 genotypes might have a locus-l...Continue Reading

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Citations

Mar 29, 2016·Journal of Cellular and Molecular Medicine·Jing HeHuimin Xia
Jan 24, 2017·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·Xin GuoWei Guo
Feb 1, 2017·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·Xin GuoWei Guo
Sep 21, 2020·Cell Biochemistry and Biophysics·Muhammad SafdarYasmeen Junejo

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Methods Mentioned

BETA
genotyping

Software Mentioned

MDR
SAS
CART

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