Caspase-1 as a regulatory molecule of lipid metabolism

Lipids in Health and Disease
Meseret Derbew MollaTesfahun Dessale Admasu

Abstract

Caspase-1 is an evolutionarily conserved inflammatory mediated enzyme that cleaves and activates inflammatory cytokines. It can be activated through the assembly of inflammasome and its major effect is to activate the pro-inflammatory cytokines; interleukin 1β (IL-1β) and interluekine-18 (IL-18). In addition to IL-1β and IL-8, several lines of evidence showed that caspase-1 targets the substrates that are involved in different metabolic pathways, including lipid metabolism. Caspase-1 regulates lipid metabolism through cytokine dependent or cytokine independent regulation of genes that involved in lipid metabolism and its regulation. To date, there are several reports on the role of caspase-1 in lipid metabolism. Therefore, this review is aimed to summarize the role of caspase-1 in lipid metabolism and its regulation.

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Citations

Oct 30, 2020·Journal of Inflammation Research·Meseret Derbew MollaTewodros Shibabaw
Aug 19, 2020·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Yuting MaMinxin Shi
Oct 17, 2021·Cell Death & Disease·Shanel DhaniBoris Zhivotovsky

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Methods Mentioned

BETA
lipidation

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