Caspase-1-independent IL-1 release mediates blister formation in autoantibody-induced tissue injury through modulation of endothelial adhesion molecules

The Journal of Immunology : Official Journal of the American Association of Immunologists
Hengameh SadeghiRalf J Ludwig

Abstract

Although reports documented aberrant cytokine expression in autoimmune bullous dermatoses (AIBDs), cytokine-targeting therapies have not been established in these disorders. We showed previously that IL-6 treatment protected against tissue destruction in experimental epidermolysis bullosa acquisita (EBA), an AIBD caused by autoantibodies to type VII collagen (COL7). The anti-inflammatory effects of IL-6 were mediated by induction of IL-1ra, and prophylactic IL-1ra administration prevented blistering. In this article, we demonstrate elevated serum concentrations of IL-1β in both mice with experimental EBA induced by injection of anti-COL7 IgG and in EBA patients. Increased IL-1α and IL-1β expression also was observed in the skin of anti-COL7 IgG-injected wild-type mice compared with the significantly less diseased IL-1R-deficient or wild-type mice treated with the IL-1R antagonist anakinra or anti-IL-1β. These findings suggested that IL-1 contributed to recruitment of inflammatory cells into the skin. Accordingly, the expression of ICAM-1 was decreased in IL-1R-deficient and anakinra-treated mice injected with anti-COL7. This effect appeared to be specifically attributable to IL-1 because anakinra blocked the upregulation of dif...Continue Reading

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Citations

Sep 1, 2016·Expert Review of Clinical Immunology·Artem VorobyevEnno Schmidt
Jan 15, 2016·The Journal of Investigative Dermatology·Michael KasperkiewiczRalf J Ludwig
Dec 12, 2017·Frontiers in Immunology·Katja BieberRalf J Ludwig
Dec 19, 2018·Expert Opinion on Biological Therapy·Mauro Alaibac
Jul 24, 2015·The Journal of Immunology : Official Journal of the American Association of Immunologists·Hiroaki IwataRalf J Ludwig
Jun 18, 2017·Frontiers in Immunology·Ralf J LudwigFalk Nimmerjahn
Apr 20, 2019·Frontiers in Immunology·Pardis-Sadat Tabatabaei-PanahReza Akbarzadeh
Jan 29, 2019·Frontiers in Medicine·Hiroshi KogaKatja Bieber
Nov 17, 2019·Seminars in Immunopathology·Christian D Sadik, Enno Schmidt
May 28, 2019·Frontiers in Immunology·Kentaro IzumiRalf J Ludwig
Mar 22, 2019·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Jian YangMian Zhang
May 26, 2020·The Journal of Investigative Dermatology·Pia StüsselKatja Bieber
Apr 13, 2021·Frontiers in Immunology·Khalaf KridinRalf J Ludwig

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