Caspase-12 is involved in stretch-induced apoptosis mediated endoplasmic reticulum stress.

Apoptosis : an International Journal on Programmed Cell Death
Qiang ZhangXiao Yuan

Abstract

It is well recognized that mandibular growth, which is caused by a variety of functional appliances, is considered to be the result of both neuromuscular and skeletal adaptations. Accumulating evidence has demonstrated that apoptosis plays an important role in the adaptation of skeletal muscle function. However, the underlying mechanism of apoptosis that is induced by stretch continues to be incompletely understood. Endoplasmic reticulum stress (ERS), a newly defined signaling pathway, initiates apoptosis. This study seeks to determine if caspase-12 is involved in stretch-induced apoptosis mediated endoplasmic reticulum stress in myoblast and its underlying mechanism. Apoptosis was assessed by Hochest staining, DAPI staining and annexin V binding and PI staining. ER chaperones, such as GRP78, CHOP and caspase-12, were determined by reverse transcription polymerase chain reaction (RT-PCR) and Western blot. Furthermore, caspase-12 inhibitor was used to value the mechanism of the caspase-12 pathway. Apoptosis of myoblast, which is subjected to cyclic stretch, was observed in a time-dependent manner. We found that GRP78 mRNA and protein were significantly increased and CHOP and caspase-12 were activated in myoblast that was exposed...Continue Reading

References

Aug 1, 1990·American Journal of Orthodontics and Dentofacial Orthopedics : Official Publication of the American Association of Orthodontists, Its Constituent Societies, and the American Board of Orthodontics·J A McNamaraT G Dischinger
Dec 1, 1973·American Journal of Orthodontics·J A McNamara
Jul 23, 1998·American Journal of Orthodontics and Dentofacial Orthopedics : Official Publication of the American Association of Orthodontists, Its Constituent Societies, and the American Board of Orthodontics·C M Mills, K J McCulloch
Feb 5, 2000·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·M MayrQ Xu
Nov 21, 2001·Nature Cell Biology·K F Ferri, G Kroemer
Mar 29, 2002·The Journal of Biological Chemistry·Rammohan V RaoH Michael Ellerby
Apr 18, 2002·American Journal of Physiology. Heart and Circulatory Physiology·Mohammad SotoudehJohn Y-J Shyy
Jun 26, 2002·The Journal of Biological Chemistry·Ying YanKenneth H Cowan
Sep 3, 2002·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Manuel MayrQingbo Xu
Oct 8, 2003·Current Cancer Drug Targets·Luke WhitesellRyan Falsey
Sep 15, 2004·Journal of Chemical Neuroanatomy·Takashi Momoi
Jun 15, 2005·Annual Review of Biochemistry·Martin Schröder, Randal J Kaufman
Sep 13, 2005·The Journal of Thoracic and Cardiovascular Surgery·Masahiro SakuraiKoichi Tabayashi
May 11, 2006·American Journal of Physiology. Cell Physiology·Ryuichi TatsumiRonald E Allen
Jul 7, 2006·Annual Review of Cell and Developmental Biology·Sebastián BernalesPeter Walter
Sep 6, 2006·EMBO Reports·Eva SzegezdiAfshin Samali
Feb 10, 2007·The FEBS Journal·Hiderou Yoshida
Feb 14, 2007·Journal of Cellular Physiology·Lucia FormigliSandra Zecchi-Orlandini
Jun 15, 2007·Physiology·Elida LaiAllen Volchuk
Apr 19, 2008·Biochemical and Biophysical Research Communications·Guanghui LiuZhiming Ge
Oct 20, 2009·European Journal of Pharmacology·Sandra J M HealyAfshin Samali
Aug 31, 2010·The International Journal of Biochemistry & Cell Biology·Jiaqiang LiuHongchen Liu
Apr 12, 2011·Apoptosis : an International Journal on Programmed Cell Death·Yue-Hui ZhangLi-Yang Dai
Jan 5, 2012·Experimental Diabetes Research·Guangjun JingSarah X Zhang
Nov 23, 2013·Apoptosis : an International Journal on Programmed Cell Death·Shu-Er ChowJong-Shyan Wang

❮ Previous
Next ❯

Citations

Mar 21, 2017·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Monruedee SukprasansapTewin Tencomnao
Jul 17, 2019·Apoptosis : an International Journal on Programmed Cell Death·Juan Ignacio BurgosMartin Vila Petroff
Jan 15, 2020·The International Journal of Neuroscience·Yingjiao LiNanchang Xie
Sep 24, 2019·Molecular Medicine Reports·Zhongsheng ZhangSichun Huang
Jan 18, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Chi-Huang ChangRobert Y Peng
Jan 18, 2020·Stem Cells and Development·Yaqi WangDapeng Ren
Apr 21, 2020·World Journal of Gastroenterology : WJG·Ru-Jia XieQin Yang
Jul 28, 2020·Saudi Journal of Biological Sciences·Farah Al-SalehMay Al-Maghrebi
Aug 20, 2021·Frontiers in Cellular Neuroscience·Yu HanXia Bi
Aug 28, 2021·International Journal of Molecular Sciences·Carmen Costas-Ferreira, Lilian R F Faro
Dec 31, 2021·Journal of Agricultural and Food Chemistry·Qin HouWangang Zhang

❮ Previous
Next ❯

Related Concepts

Related Feeds

Blood And Marrow Transplantation

The use of hematopoietic stem cell transplantation or blood and marrow transplantation (bmt) is on the increase worldwide. BMT is used to replace damaged or destroyed bone marrow with healthy bone marrow stem cells. Here is the latest research on bone and marrow transplantation.

Apoptotic Caspases

Apoptotic caspases belong to the protease enzyme family and are known to play an essential role in inflammation and programmed cell death. Here is the latest research.

B-Cell Lymphoma

B-cell lymphomas include lymphomas that affect B cells. This subtype of cancer accounts for over 80% of non-Hodgkin lymphomas in the US. Here is the latest research.

Apoptosis

Apoptosis is a specific process that leads to programmed cell death through the activation of an evolutionary conserved intracellular pathway leading to pathognomic cellular changes distinct from cellular necrosis

Related Papers

Hua xi kou qiang yi xue za zhi = Huaxi kouqiang yixue zazhi = West China journal of stomatology
Xian DingXiao Yuan
European Spine Journal : Official Publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society
Yue-Hui ZhangLi-Yang Dai
© 2022 Meta ULC. All rights reserved