Caspase-3 expression is reduced, in the absence of cleavage, in terminally differentiated normal oral epithelium but is increased in oral squamous cell carcinomas and correlates with tumour stage

The Journal of Pathology
Angela HagueSelvam Thavaraj

Abstract

Oral carcinomas are known to have a greater apoptotic index than normal oral epithelium, evident as shrinking cells with condensed chromatin. In this study, these morphologically apoptotic cells stained positively for cleaved (active) caspase-3. In normal oral epithelium, cleaved caspase-3 positive-cells were only rarely detected. The terminally differentiated surface epithelial layers did not express cleaved caspase-3. The caspase-3 pro-enzyme showed a gradient of expression in normal oral epithelium, decreasing with differentiation. No expression was detectable in surface epithelial layers. Lack of expression of the major 'executioner' caspase-3 may, at least in part, explain differences in morphology between terminally differentiated and apoptotic cells. In cancers of different tissue origins, caspase-3 pro-enzyme expression can be either increased or decreased compared with normal tissue counterparts. To determine how caspase-3 expression alters during oral carcinogenesis, caspase-3 expression was compared in 39 samples of normal oral epithelium and 54 oral squamous cell carcinomas. Squamous cell carcinomas had more intense caspase-3 staining than normal epithelium (p < 0.001). Moreover, within the oral squamous cell carcin...Continue Reading

Citations

Sep 26, 2009·Anatomical Science International·Mitsuko MoriguchiTakaaki Yanagisawa
Oct 1, 2011·Molecular & Cellular Proteomics : MCP·Zhixiang WuBernhard Kuster
May 31, 2006·Expert Opinion on Investigational Drugs·Kathryn TaylorCaroline Dive
Nov 6, 2010·Oral Oncology·E Kenneth Parkinson
Dec 15, 2007·Pathology, Research and Practice·Daniel RibeiroMariângela E A Marques
Feb 14, 2008·Growth Hormone & IGF Research : Official Journal of the Growth Hormone Research Society and the International IGF Research Society·Garrett BradySupriya Kapas
Mar 30, 2007·Journal of Oral Pathology & Medicine : Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology·Andreas KaratsaidisKarl Schenck
Oct 11, 2016·Journal of Oral and Maxillofacial Pathology : JOMFP·Veeran VeeravarmalMohamed Hanifa Mohamed Nassar
Aug 25, 2016·Journal of Applied Oral Science : Revista FOB·Ana Flávia Schueler de Assumpção LeiteSimone de Queiroz Chaves Lourenço
Feb 13, 2007·The Journal of Biological Chemistry·Meilang XueChristopher J Jackson
Nov 24, 2005·Hematology·Aaron D Schimmer, Shadi Dalili
May 19, 2012·Applied Immunohistochemistry & Molecular Morphology : AIMM·Juliana Hintz Germanos ScheidtFernanda Gonçalves Salum

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