Abstract
Oral carcinomas are known to have a greater apoptotic index than normal oral epithelium, evident as shrinking cells with condensed chromatin. In this study, these morphologically apoptotic cells stained positively for cleaved (active) caspase-3. In normal oral epithelium, cleaved caspase-3 positive-cells were only rarely detected. The terminally differentiated surface epithelial layers did not express cleaved caspase-3. The caspase-3 pro-enzyme showed a gradient of expression in normal oral epithelium, decreasing with differentiation. No expression was detectable in surface epithelial layers. Lack of expression of the major 'executioner' caspase-3 may, at least in part, explain differences in morphology between terminally differentiated and apoptotic cells. In cancers of different tissue origins, caspase-3 pro-enzyme expression can be either increased or decreased compared with normal tissue counterparts. To determine how caspase-3 expression alters during oral carcinogenesis, caspase-3 expression was compared in 39 samples of normal oral epithelium and 54 oral squamous cell carcinomas. Squamous cell carcinomas had more intense caspase-3 staining than normal epithelium (p < 0.001). Moreover, within the oral squamous cell carcin...Continue Reading
Citations
Nov 17, 2004·The Journal of Pathology·Selvam ThavarajStephen S Prime
Sep 26, 2009·Anatomical Science International·Mitsuko MoriguchiTakaaki Yanagisawa
Oct 1, 2011·Molecular & Cellular Proteomics : MCP·Zhixiang WuBernhard Kuster
Mar 9, 2013·PloS One·Thejaswini VenkateshArun Kumar
May 31, 2006·Expert Opinion on Investigational Drugs·Kathryn TaylorCaroline Dive
Nov 6, 2010·Oral Oncology·E Kenneth Parkinson
Dec 15, 2007·Pathology, Research and Practice·Daniel RibeiroMariângela E A Marques
Feb 14, 2008·Growth Hormone & IGF Research : Official Journal of the Growth Hormone Research Society and the International IGF Research Society·Garrett BradySupriya Kapas
Mar 30, 2007·Journal of Oral Pathology & Medicine : Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology·Andreas KaratsaidisKarl Schenck
May 13, 2006·Experimental Dermatology·Dagmar SimonHans-Uwe Simon
May 27, 2016·Cancer Medicine·Min ZhangHongjun Yu
Oct 11, 2016·Journal of Oral and Maxillofacial Pathology : JOMFP·Veeran VeeravarmalMohamed Hanifa Mohamed Nassar
Aug 25, 2016·Journal of Applied Oral Science : Revista FOB·Ana Flávia Schueler de Assumpção LeiteSimone de Queiroz Chaves Lourenço
Dec 13, 2016·Oncogene·H JanakiramanV Palanisamy
Feb 17, 2018·Cell Death & Disease·Chun LinXuenong Li
Jul 7, 2005·British Journal of Cancer·D R CamidgeA M Hughes
Apr 2, 2019·Natural Product Research·Asma Bini ArabaFahad Zadjali
Apr 28, 2011·British Journal of Cancer·J WoodA Hague
Feb 13, 2007·The Journal of Biological Chemistry·Meilang XueChristopher J Jackson
Nov 24, 2005·Hematology·Aaron D Schimmer, Shadi Dalili
Nov 16, 2017·Oncotarget·Jer-Shyung HuangPei-Feng Liu
Jul 8, 2020·Biomolecules·Jenya Konikov-RozenmanShulamit B Wallach-Dayan
Oct 5, 2019·Cell Death & Disease·Ambreen RehmanHong Wan
May 19, 2012·Applied Immunohistochemistry & Molecular Morphology : AIMM·Juliana Hintz Germanos ScheidtFernanda Gonçalves Salum