Caspase-8: The double-edged sword

Biochimica Et Biophysica Acta. Reviews on Cancer
Ranadip MandalKlaus Strebhardt

Abstract

Caspase-8 is a cysteine - aspartate specific protease that classically triggers the extrinsic apoptotic pathway, in response to the activation of cell surface Death Receptors (DRs) like FAS, TRAIL-R and TNF-R. Besides it's roles in triggering death receptor-mediated apoptosis, Caspase-8 has also been implicated in the onsets of anoikis, autophagy and pyroptosis. Furthermore, Caspase-8 also plays a crucial pro-survival function by inhibiting an alternative form of programmed cell death called necroptosis. Low expression levels of pro-Caspase-8 is therefore associated with the malignant transformation of cancers. However, the long-held notion that pro-Caspase-8 expression/activity is generally lost in most cancers, thereby contributing to apoptotic escape and enhanced resistance to anti-cancer therapeutics, has been found to be true for only a minority of cancers types. In the majority of cases, pro-Caspase-8 expression is maintained and sometimes elevated, while it's apoptotic activity is regulated through different mechanisms. This supports the notion that the non-apoptotic functions of Caspase-8 offer growth advantage in these cancer types and have, therefore, gained renewed interest in the recent years. In light of these reas...Continue Reading

References

Jan 1, 1995·Immunology Today·S Nagata, T Suda
Aug 1, 1996·The Journal of Cell Biology·S M FrischP Y Chan-Hui
Oct 18, 1996·Cell·E S AlnemriJ Yuan
Feb 28, 1998·The Journal of Biological Chemistry·M MuzioV M Dixit
May 9, 1998·Proceedings of the National Academy of Sciences of the United States of America·R A MacCorkleD M Spencer
May 20, 1998·Immunity·C M WalshS M Hedrick
Jul 11, 1998·Molecular Cell·X YangD Baltimore
Jan 9, 1999·The Journal of Biological Chemistry·C ScaffidiM E Peter
Sep 29, 1999·Proceedings of the National Academy of Sciences of the United States of America·G S Salvesen, V M Dixit
Dec 1, 1999·Cell Death and Differentiation·D W Nicholson
Dec 28, 1999·Annual Review of Cell and Developmental Biology·I BudihardjoX Wang
Jun 22, 2000·Biochemical and Biophysical Research Communications·T HoriuchiK Hayashi
Jun 29, 2000·Annual Review of Biochemistry·W C EarnshawS H Kaufmann
Oct 26, 2000·Nature·M O Hengartner
Oct 26, 2000·Nature·T RichA H Wyllie
Sep 27, 2001·Cell and Tissue Research·A van der Flier, A Sonnenberg
Oct 31, 2001·The Journal of Cell Biology·D G StupackD A Cheresh
Mar 5, 2002·Nature Medicine·David A Cheresh, Dwayne G Stupack
May 23, 2002·Biochimie·Anne-Sophie BelzacqCatherine Brenner
May 23, 2002·Biochimie·Kelvin CainGerald M Cohen
Jun 11, 2002·The Journal of Biological Chemistry·Bolin LiuZhen Fan
Aug 13, 2002·Cancer Biology & Therapy·Narayan ShivapurkarAdi F Gazdar
Sep 7, 2002·The Journal of Biological Chemistry·Olivier MicheauMarkus G Grütter
Oct 31, 2002·Neoplasia : an International Journal for Oncology Research·Nesrin Ozören, Wafik S El-Deiry
Nov 29, 2002·Nature Medicine·Barbara BanelliMassimo Romani
Mar 7, 2003·Molecular Cell·Kelly M BoatrightGuy S Salvesen
Mar 7, 2003·Molecular Cell·Mrudula DonepudiMarkus G Grütter
Mar 26, 2003·Genes & Development·Leonardo SalmenaRazqallah Hakem
Jun 21, 2003·The Journal of Immunology : Official Journal of the American Association of Immunologists·Daniel R BeisnerCraig M Walsh
Aug 13, 2003·The EMBO Journal·David W ChangXiaolu Yang
Sep 2, 2003·Nature Reviews. Immunology·Bharat B Aggarwal
Jan 30, 2004·International Journal of Cancer. Journal International Du Cancer·Bodo SchniewindHendrik Ungefroren

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Citations

Oct 8, 2020·Cancer Metastasis Reviews·Izabela KostovaKlaus Strebhardt
Nov 17, 2020·Frontiers in Cell and Developmental Biology·Juan A MonteroJuan M Hurle
Mar 2, 2021·Biochimica Et Biophysica Acta. Molecular Cell Research·Sean M PostPeter P Ruvolo
Apr 4, 2021·Biomolecules·You-Take Oh, Shi-Yong Sun
May 25, 2021·International Journal of Cancer. Journal International Du Cancer·Mingxia JiangYanjing Li
Jun 3, 2021·Cancers·Ranadip MandalKlaus Strebhardt

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