Caspases inhibition decreases neurological sequelae in meningitis

Critical Care Medicine
Jose IrazuztaBasilia Zingarelli

Abstract

To evaluate the effects of sustained caspase inhibition during the acute phase of meningitis-induced brain injury. Changes in neurobehavioral performance were the primary outcome variables. Randomized prospective animal study. University research laboratory. Male Wistar rats. Animals underwent a basilar cistern inoculation of group B Streptococci to induce meningitis. Sixteen hours later animals were randomized to receive Bocaspartyl (OMe)-fluoromethyketone (BAF) for 4 days or placebo in addition to antibiotic therapy. The assessment of neurobehavioral performance was started 7 days after initiation of treatment and continued for the following 3 wks. A subgroup underwent early kill, at 5 days, to evaluate caspase 3 activity in brain tissue. There was a group of Sham instrumented animals. BAF decreased caspase 3 activation in meningitic animals. There were no significant motor deficit differences between the infected groups. Cognitive performance was significantly improved in the BAF group. These findings demonstrate that sustained systemic administration of BAF inhibits caspase 3 activation and decreases neurologic sequelae in a rat model of bacterial meningitis.

References

Apr 10, 1999·Journal of Neuropathology and Experimental Neurology·R NauW Brück
Apr 1, 2000·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·O F AlmeidaT M Michaelidis
Oct 12, 2000·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·L J Burke, A Baniahmad
Nov 15, 2002·The New England Journal of Medicine·Jan de GansUNKNOWN European Dexamethasone in Adulthood Bacterial Meningitis Study Investigators
Mar 29, 2003·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Natasa TerzicSabera Ruzdijic
Jun 19, 2003·Pediatric Critical Care Medicine : a Journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies·Patrick M. KochanekLarry W. Jenkins
Jun 26, 2004·Journal of Neuropathology and Experimental Neurology·Christian GianinazziStephen L Leib
Oct 27, 2004·Intensive Care Medicine·Jose IrazuztaBasilia Zingarelli
Jun 21, 2006·The Journal of Immunology : Official Journal of the American Association of Immunologists·Seija LehnardtTimothy Vartanian
Jan 11, 2007·Pediatric Research·Patrick J G H KamphuisVictor M Wiegant

❮ Previous
Next ❯

Citations

Jun 19, 2010·Journal of Neural Transmission·Tatiana BarichelloJoão Quevedo
Feb 4, 2012·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·T BarichelloA L Teixeira
May 2, 2008·Critical Care Medicine·Michael Eisenhut
Jul 8, 2011·Clinical Microbiology Reviews·Barry B Mook-KanamoriDiederik van de Beek
May 27, 2014·Journal of Neuroimmunology·Tatiana BarichelloJoão Quevedo
Sep 3, 2013·Translational Research : the Journal of Laboratory and Clinical Medicine·Tatiana BarichelloJoão Quevedo
Jun 26, 2010·Brain Research Bulletin·Tatiana BarichelloEmilio L Streck
Sep 8, 2009·Neuroscience Letters·Tatiana BarichelloFelipe Dal-Pizzol
May 12, 2009·Médecine et maladies infectieuses·P Chavanet
May 5, 2009·Brain Research Bulletin·Tatiana BarichelloEmilio L Streck
Aug 27, 2015·Critical Care : the Official Journal of the Critical Care Forum·Cédric BretonnièreChristophe Guitton
Sep 23, 2014·Journal of Neural Transmission·Tatiana BarichelloJoão Quevedo
Oct 23, 2012·European Journal of Pharmacology·Tatiana BarichelloAntônio Lucio Teixeira
Jun 7, 2014·Experimental Biology and Medicine·Tatiana BarichelloJoão Quevedo

❮ Previous
Next ❯

Related Concepts

Related Feeds

Brain Injury & Trauma

brain injury after impact to the head is due to both immediate mechanical effects and delayed responses of neural tissues.

Apoptotic Caspases

Apoptotic caspases belong to the protease enzyme family and are known to play an essential role in inflammation and programmed cell death. Here is the latest research.

Bacterial Meningitis

Bacterial meningitis continues to be an important cause of mortality and morbidity throughout the world. Here is the latest research.

Bacterial Meningitis (ASM)

Bacterial meningitis continues to be an important cause of mortality and morbidity throughout the world. Here is the latest research.

Related Papers

Journal of Neural Transmission
Tatiana BarichelloJoão Quevedo
Journal of Neurology, Neurosurgery, and Psychiatry
Martine HoogmanBen A Schmand
© 2022 Meta ULC. All rights reserved