Caspases maintain tissue integrity by an apoptosis-independent inhibition of cell migration and invasion

Nature Communications
Anna Gorelick-AshkenaziEli Arama

Abstract

Maintenance of tissue integrity during development and homeostasis requires the precise coordination of several cell-based processes, including cell death. In animals, the majority of such cell death occurs by apoptosis, a process mediated by caspase proteases. To elucidate the role of caspases in tissue integrity, we investigated the behavior of Drosophila epithelial cells that are severely compromised for caspase activity. We show that these cells acquire migratory and invasive capacities, either within 1-2 days following irradiation or spontaneously during development. Importantly, low levels of effector caspase activity, which are far below the threshold required to induce apoptosis, can potently inhibit this process, as well as a distinct, developmental paradigm of primordial germ cell migration. These findings may have implications for radiation therapy in cancer treatment. Furthermore, given the presence of caspases throughout metazoa, our results could imply that preventing unwanted cell migration constitutes an ancient non-apoptotic function of these proteases.

References

Oct 1, 1992·Biochemistry and Cell Biology = Biochimie Et Biologie Cellulaire·R N JohnstonR B Pai
Jul 1, 1990·Cancer Metastasis Reviews·P Frost, Y Chernajovsky
May 27, 1997·Proceedings of the National Academy of Sciences of the United States of America·M MilánA García-Bellido
Aug 28, 1998·Science·A Ashkenazi, V M Dixit
Dec 28, 1999·Annual Review of Cell and Developmental Biology·I BudihardjoX Wang
Oct 26, 2000·Nature·M O Hengartner
Mar 30, 2001·The Journal of Biological Chemistry·S Tu, R A Cerione
Jun 25, 2002·Genes & Development·Yikang S RongKent G Golic
Jul 23, 2004·Current Biology : CB·Ana C Santos, Ruth Lehmann
Jul 29, 2004·DNA Repair·Edgardo R Parrilla-CastellarLarry Karnitz
Feb 24, 2006·Nature Reviews. Molecular Cell Biology·Jean Paul Thiery, Jonathan P Sleeman
May 9, 2006·Cancer Metastasis Reviews·Elena I Deryugina, James P Quigley
Jun 21, 2006·Proceedings of the National Academy of Sciences of the United States of America·Anita WichmannTin Tin Su
Sep 19, 2006·Nature Neuroscience·Darren W WilliamsJames W Truman
Feb 24, 2007·Nature Reviews. Molecular Cell Biology·Andrea Page-McCawZena Werb
Aug 19, 2007·Seminars in Cell & Developmental Biology·Andrea Page-McCaw
Apr 29, 2008·Advances in Experimental Medicine and Biology·Guy S Salvesen, Stefan J Riedl
Mar 18, 2009·Apoptosis : an International Journal on Programmed Cell Death·John F FullardNicholas E Baker
Jun 3, 2009·The Journal of Clinical Investigation·Raghu Kalluri, Robert A Weinberg
Sep 8, 2010·Current Opinion in Cell Biology·Peter D Mace, Stefan J Riedl
Sep 17, 2010·Journal of Cell Science·Shawn B Bratton, Guy S Salvesen
Nov 3, 2010·Advances in Cancer Research·Joanne SmithDavid A Gillespie
Mar 8, 2011·Cell·Douglas Hanahan, Robert A Weinberg
Mar 23, 2011·The Journal of Cell Biology·Buzz Baum, Marios Georgiou
Feb 22, 2012·The Journal of Cell Biology·Anat Florentin, Eli Arama
Jun 23, 2012·Cell Death and Differentiation·B MollereauG Morata
Nov 28, 2012·Proceedings of the National Academy of Sciences of the United States of America·Andrés DekantyMarco Milán
Jan 12, 2013·EMBO Reports·Vivek A RudrapatnaRoss L Cagan
Jan 15, 2013·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·Laura Wegener Parfrey, Daniel J G Lahr
Apr 9, 2013·Structure·Shujun Yuan, Christopher W Akey
Feb 24, 2015·The Biochemical Journal·Karen McLuskey, Jeremy C Mottram
Mar 10, 2015·Nature Communications·Han ChenXionglei He
May 27, 2015·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·Kazuhiro SakamakiDavid J Miller
Jul 16, 2015·The Journal of Pathology·Gordon T Brown, Graeme I Murray

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Citations

Apr 24, 2019·Cancer Research and Treatment : Official Journal of Korean Cancer Association·Nan LiZhenhua Lin
Jul 28, 2020·Development·Piya Ghose, Shai Shaham
Nov 13, 2020·The FEBS Journal·Camila Castillo FerrerGabriel Ichim
Dec 9, 2020·The Journal of Immunology : Official Journal of the American Association of Immunologists·Eric J GapudAntony Rosen
Jun 11, 2020·Cell Reports·Kevin BerthenetGabriel Ichim
May 6, 2020·Developmental Cell·Olya Yarychkivska, Shai Shaham
Aug 28, 2021·International Journal of Molecular Sciences·Caitlin Hounsell, Yun Fan
Nov 14, 2021·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Shainy Ojha, Madhu G Tapadia

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Methods Mentioned

BETA
transgenic
GTPases
dissections
dissection
X-ray

Software Mentioned

Imaris
Zen
Adobe Photoshop
Raeppli
Zeiss
MATLAB
STATISTICA
ImageJ
R

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