Caspases shutdown nonsense-mediated mRNA decay during apoptosis

Cell Death and Differentiation
J JiaF Lejeune

Abstract

Nonsense-mediated mRNA decay (NMD) is an mRNA surveillance mechanism that plays integral roles in eliminating mRNAs with premature termination codons to prevent the synthesis of truncated proteins that could be pathogenic. One response to the accumulation of detrimental proteins is apoptosis, which involves the activation of enzymatic pathways leading to protein and nucleic acid cleavage and culminating in cell death. It is not clear whether NMD is required to ensure the accurate expression of apoptosis genes or is no longer necessary since cytotoxic proteins are not an issue during cell death. The present study shows that caspases cleave the two NMD factors UPF1 and UPF2 during apoptosis impairing NMD. Our results demonstrate a new regulatory pathway for NMD that occurs during apoptosis and provide evidence for role of the UPF cleaved fragments in apoptosis and NMD inhibition.

References

Jun 1, 1992·Proceedings of the National Academy of Sciences of the United States of America·A L CozensD C Gruenert
Jan 1, 1994·American Journal of Respiratory Cell and Molecular Biology·A L CozensD C Gruenert
Oct 1, 1995·Experimental Neurology·J Y KohD W Choi
Oct 18, 1996·Cell·E S AlnemriJ Yuan
Oct 1, 1996·The Journal of Experimental Medicine·S A SusinG Kroemer
Jun 17, 1998·The EMBO Journal·R ThermannA E Kulozik
Jul 11, 2002·Cell Death and Differentiation·X J ZhangY F Shi
Jun 17, 2003·Proceedings of the National Academy of Sciences of the United States of America·Jack T Nguyen, James A Wells
Nov 25, 2003·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Nicola A JohnsonCristin G Print
Jul 27, 2004·Protein Science : a Publication of the Protein Society·Yigong Shi
Oct 7, 2004·Journal of Cystic Fibrosis : Official Journal of the European Cystic Fibrosis Society·D C GruenertR A Frizzell
Jul 23, 2005·Cellular Physiology and Biochemistry : International Journal of Experimental Cellular Physiology, Biochemistry, and Pharmacology·Ana Carina da PaulaMargarida D Amaral
Jan 27, 2007·BMC Bioinformatics·Lawrence J K WeeShoba Ranganathan
Jun 15, 2007·Toxicologic Pathology·Susan Elmore
Jul 29, 2008·Biochimica Et Biophysica Acta·Oliver MühlemannRodolfo Zamudio Orozco
Jun 9, 2009·Nature Structural & Molecular Biology·Wai-Kin ChanMiles F Wilkinson
Jun 23, 2010·Proceedings of the National Academy of Sciences of the United States of America·David R McIlwainTak W Mak
Sep 4, 2012·Orphanet Journal of Rare Diseases·Sara Gonzalez-HilarionFabrice Lejeune
Mar 2, 2013·Cell Death and Differentiation·M Suzanne, H Steller
Mar 19, 2013·Biochimica Et Biophysica Acta·Rachid KaramMiles F Wilkinson
Mar 20, 2013·Molecular and Cellular Biology·Jordan WengrodLawrence B Gardner
Nov 26, 2013·Nucleic Acids Research·Marcello ClericiStephen Cusack
Feb 21, 2014·Molecules and Cells·Maximilian Wei-Lin Popp, Lynne E Maquat

❮ Previous
Next ❯

Citations

Jan 17, 2016·Nucleic Acids Research·Nele HugJavier F Cáceres
Apr 14, 2015·Biomolecules·Tzu-Wei ChuangWoan-Yuh Tarn
May 14, 2016·Wiley Interdisciplinary Reviews. RNA·Evangelos D KarousisOliver Mühlemann
Dec 23, 2017·Nucleic Acids Research·Xin HanTangliang Li
Apr 25, 2020·Pathogens·Léa ProchassonVincent Mocquet
Apr 18, 2019·Nature Reviews. Molecular Cell Biology·Tatsuaki KurosakiLynne E Maquat
May 16, 2017·Cellular and Molecular Life Sciences : CMLS·Alexandra E Goetz, Miles Wilkinson
Aug 27, 2019·Frontiers in Immunology·Magalí Rey-CamposAntonio Figueras
Sep 4, 2017·Seminars in Cell & Developmental Biology·Sofia NasifOliver Mühlemann
Nov 10, 2017·Current Opinion in Genetics & Development·Maximilian W Popp, Lynne E Maquat
May 1, 2021·Molecular Cancer·Gonçalo NogueiraLuísa Romão
Jun 20, 2021·Biochemical and Biophysical Research Communications·Leng HanEnyong Dai

❮ Previous
Next ❯

Related Concepts

Related Feeds

Apoptosis

Apoptosis is a specific process that leads to programmed cell death through the activation of an evolutionary conserved intracellular pathway leading to pathognomic cellular changes distinct from cellular necrosis

Apoptotic Caspases

Apoptotic caspases belong to the protease enzyme family and are known to play an essential role in inflammation and programmed cell death. Here is the latest research.