PMID: 15241246Jul 9, 2004Paper

Caspases, the enemy within, and their role in oxidative stress-induced apoptosis of inner ear sensory cells

Otology & Neurotology : Official Publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology
T R Van De WaterT J Balkany

Abstract

This review covers the general roles of members of the cysteine protease family of caspases in the process of apoptosis (programmed cell death) looking at their participation in both the "extrinsic" cell death receptor and the "intrinsic" mitochondrial cell death pathways. It defines the difference between initiator and effector caspases and shows the progression of caspase activations that ends up in the apoptotic cell death and elimination of a damaged cell. The review then presents what is currently know about the participation of caspases in the programmed cell death of inner ear sensory cells during the process of normal development and maturation of the inner ear and their importance in this process as illustrated by the results of caspase-3 gene knockout experiments. The participation of specific caspases and the sequence of their activation in the elimination (apoptosis) of damaged sensory cells from adult inner ears after an injury that generates oxidative stress are reviewed. Both the possibility and the potential efficacy of caspase inhibition with a broad-spectrum pancaspase inhibitor as an interventional therapy to treat and rescue oxidative stress-damaged inner ear sensory cells from apoptosis are presented and di...Continue Reading

References

Mar 19, 1996·Proceedings of the National Academy of Sciences of the United States of America·D L Vaux, A Strasser
Apr 22, 1999·Annals of Neurology·J B SchulzM A Moskowitz
Dec 28, 1999·Annual Review of Cell and Developmental Biology·I BudihardjoX Wang
May 26, 2001·Biochemical and Biophysical Research Communications·H MorishitaK I Nakayama
Oct 13, 2001·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·R W KeaneW D Dietrich
Dec 6, 2001·Proceedings of the National Academy of Sciences of the United States of America·M RenatusG S Salvesen
Apr 26, 2002·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Guodong CaoJun Chen
Jun 8, 2002·Audiology & Neuro-otology·Philippe P LefebvreThomas R Van De Water
Aug 13, 2002·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Christian Lesuisse, Lee J Martin
Nov 6, 2002·Journal of the Association for Research in Otolaryngology : JARO·Alan G ChengEdwin W Rubel
Mar 26, 2003·Cell Death and Differentiation·U FischerK Schulze-Osthoff
Oct 10, 2003·Journal of the Association for Research in Otolaryngology : JARO·Thomas M NicoteraDonald Henderson
Oct 22, 2003·Cell·Janice L Pellino, Erik J Sontheimer

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Citations

Jan 23, 2008·HNO·S Pfannenstiel, M Praetorius
Oct 8, 2008·Apoptosis : an International Journal on Programmed Cell Death·Sherif F TadrosRobert D Frisina
Sep 5, 2006·Otolaryngology--head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery·Oliver Adunka, Jan Kiefer
Feb 1, 2006·Ear and Hearing·Donald HendersonBo Hua Hu
Sep 20, 2006·Otology & Neurotology : Official Publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology·Kathryn L HallCliff A Megerian
Jan 11, 2007·Otology & Neurotology : Official Publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology·Dylan K ChanMichael G Kaplitt
Sep 15, 2005·Current Opinion in Otolaryngology & Head and Neck Surgery·Maroun T SemaanCliff A Megerian
Mar 6, 2012·Otology & Neurotology : Official Publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology·Sofia WaissbluthSam J Daniel
Jul 20, 2010·Current Opinion in Otolaryngology & Head and Neck Surgery·Maroun T Semaan, Cliff A Megerian
Jun 8, 2000·Annals of the New York Academy of Sciences·R KopkeT Van de Water
Nov 1, 2003·The Journal of the Acoustical Society of America·Colette BoëxMarco Pelizzone
Oct 13, 2011·BMC Neuroscience·Tomoko MakishimaScott Wood
Aug 26, 2014·Neural Computation·Beatrice A GolombJanis B Ritchie
Jun 1, 2012·Expert Opinion on Drug Discovery·Debashree MukherjeaSandeep Sheth
Sep 16, 2008·Hearing Research·Kevin K Ohlemiller
Sep 10, 2008·Hearing Research·Bo Hua HuDonald Henderson
Mar 18, 2008·Neuroscience Research·Daisuke YamashitaKaoru Ogawa
Nov 23, 2006·Neurobiology of Disease·Jun MaruyamaJosef M Miller
Jul 28, 2011·Journal of Cellular Physiology·Marina Di DomenicoEttore Cassandro
May 25, 2012·Acta Oto-laryngologica·Min-Hyun ParkSeung-Ha Oh
Aug 7, 2012·The Journal of Toxicological Sciences·Li XiaShankai Yin
May 8, 2015·BioMed Research International·Alan M RobinsonClaus-Peter Richter
May 23, 2017·Comparative Biochemistry and Physiology. Toxicology & Pharmacology : CBP·Giulianna Echeverria MacedoThaís Posser
Oct 27, 2007·Free Radical Research·Xiaorui ShiAlfred Nuttall
Feb 13, 2013·Otolaryngology--head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery·Christine DinhThomas R Van De Water
Dec 23, 2017·Evidence-based Complementary and Alternative Medicine : ECAM·Min Soo KimKyung Song

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