Caspofungin as first-line therapy for the treatment of invasive aspergillosis after thoracic organ transplantation

The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation
Jan GroetznerBruno Reichart

Abstract

Although amphotericin was the gold standard in the treatment of invasive aspergillosis in transplant recipients, nephrotoxicity and lack of efficacy often limits its use. Itraconazole is better tolerated but less efficacious and influences immunosuppressant trough levels significantly. We report our first clinical experience with the use of caspofungin as first-line therapy in heart and lung transplant recipients with invasive aspergillosis. Caspofungin was administered at 50 to 70 mg/day in heart and lung transplant recipients with renal impairment while invasive aspergillosis was diagnosed and classified. Aspergillus serology, serologic inflammatory markers, and X-rays were taken to monitor infectious activity. Creatinine and immunosuppressant trough levels were monitored closely. Invasive aspergillosis was diagnosed by chest X-ray, serology, and positive sputum in 1 heart-lung, 7 heart, and 4 single-lung transplant recipients, and caspofungin was administered for a mean time of 21 +/- 9 days. Basic immunosuppressants were tacrolimus in 9 patients or cyclosporine in 3. Complete remission was achieved in 10 patients (83%). Adverse effects of caspofungin were fever in 6, diarrhea in 3, and neutropenia in 1. Renal function remai...Continue Reading

References

Sep 1, 1990·Journal of the American Academy of Dermatology·D W DenningD A Stevens
Sep 1, 1996·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·D W Denning
Apr 9, 1999·Medicine·D L Paterson, N Singh
Dec 10, 1999·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·J H Rex, T J Walsh
Apr 19, 2000·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·D A StevensG A Pankey
Feb 15, 2001·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·S J LinS M Teutsch
Oct 20, 2001·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·N Singh
Jul 18, 2002·Antimicrobial Agents and Chemotherapy·William R KirkpatrickThomas F Patterson
Jul 19, 2002·Transplant Infectious Disease : an Official Journal of the Transplantation Society·C A SableM J DiNubile
Aug 9, 2002·The New England Journal of Medicine·Raoul HerbrechtUNKNOWN Invasive Fungal Infections Group of the European Organisation for Research and Treatment of Cancer and the Global Aspergillu
Mar 17, 2004·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·Patricia MuñozManuel Desco
Dec 21, 2004·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·J Stephen DummerAaron P Milstone
Apr 6, 2005·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Pranatharthi H Chandrasekar, James I Ito
Sep 7, 2005·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·Pratibha SinghalAtul C Mehta
Nov 22, 2005·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·Oksana Anatolia ShlobinReda Girgis

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Citations

Aug 13, 2010·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·J W HiemenzT J Walsh
Nov 22, 2005·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·Oksana Anatolia ShlobinReda Girgis
Sep 1, 1996·The Annals of Thoracic Surgery·T M BeaverF L Grover
Sep 26, 2001·Infectious Disease Clinics of North America·R Patel
Aug 10, 2000·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·P MuñozE Bouza
Aug 7, 2002·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·Najib SafieddineC M Guiraurdon
Mar 14, 2003·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·Nina Singh, Shahid Husain
Mar 24, 2009·Current Opinion in Pulmonary Medicine·Amparo Solé, Miguel Salavert
Aug 29, 2013·Case Reports in Transplantation·Sonia RadunzFuat H Saner
May 8, 2015·Expert Review of Anti-infective Therapy·Eline W MuilwijkRoger J M Brüggemann
Nov 7, 2012·Enfermedades infecciosas y microbiología clínica·Joan GavaldàAlbert Pahissa
Jul 14, 2012·Thoracic Surgery Clinics·Chad A WittRamsey R Hachem
Apr 9, 2011·Enfermedades infecciosas y microbiología clínica·Jesús FortúnUNKNOWN Grupo de Estudio de Micología Médica de la SEIMC (GEMICOMED)
Mar 1, 2011·Revue de pneumologie clinique·C KnoopM Estenne
Apr 21, 2010·Revue des maladies respiratoires·C KnoopM Estenne
Dec 29, 2009·International Journal of Antimicrobial Agents·Hsin-Yun Sun, Nina Singh
Feb 10, 2009·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·Víctor MonforteAntonio Román
Jul 29, 2008·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·Toby M MaherGilles D Dreyfus
May 28, 2008·Mycoses·W J Heinz, H Einsele
Mar 8, 2013·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·J Trofe-ClarkUNKNOWN AST Infectious Diseases Community of Practice
Jan 29, 2011·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·C F NeohD C M Kong
Jan 28, 2010·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·N SinghUNKNOWN AST Infectious Diseases Community of Practice
Jan 15, 2010·Transplant Infectious Disease : an Official Journal of the Transplantation Society·M WinklerM Shivaprakash
Aug 29, 2009·Clinical Transplantation·Supha K ArthursRaymund R Razonable
May 9, 2014·Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases·J GavaldàM Cuenca-Estrella
Sep 28, 2016·Current Clinical Microbiology Reports·Sheena MukkadaMiguela A Caniza
Jun 22, 2011·American Journal of Health-system Pharmacy : AJHP : Official Journal of the American Society of Health-System Pharmacists·Shannon L Holt, Richard H Drew
Jun 30, 2019·Mycoses·Oliver A CornelyUNKNOWN Mycoses Study Group Education and Research Consortium (MSG-ERC) and the European Confederation of Medical Mycology (ECMM)
Jun 27, 2018·ESMO Open·Matthias Gerhard VossenFlorian Thalhammer
Jun 17, 2014·Internal Medicine·Fumio KurosakiYukihiko Sugiyama
Oct 7, 2020·European Journal of Hospital Pharmacy. Science and Practice·Shuqiao ChengTao Yin

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Aspergillosis is the name given to a wide variety of diseases caused by infection by fungi of the genus Aspergillus. Aspergillosis occurs in chronic or acute forms which are clinically very distinct. Most cases of acute aspergillosis occur in patients with severely compromised immune systems. Chronic colonization or infection can cause complications in people with underlying respiratory illnesses. Discover the latest research on aspergillosis here.

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