Caspofungin Modulates Ryanodine Receptor-Mediated Calcium Release in Human Cardiac Myocytes

Antimicrobial Agents and Chemotherapy
Christian KochMichael Henrich

Abstract

Recent studies showed that critically ill patients might be at risk for hemodynamic impairment during caspofungin (CAS) therapy. The aim of our present study was to examine the mechanisms behind CAS-induced cardiac alterations. We revealed a dose-dependent increase in intracellular Ca2+ concentration ([Ca2+]i) after CAS treatment. Ca2+ ions were found to be released from intracellular caffeine-sensitive stores, most probably via the activation of ryanodine receptors.

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Citations

Nov 22, 2019·International Journal of Clinical Pharmacy·Christian KochChristoph Lichtenstern
Nov 11, 2021·Journal of the European Academy of Dermatology and Venereology : JEADV·H ColbocS Ingen-Housz-Oro

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