Caspr3-Deficient Mice Exhibit Low Motor Learning during the Early Phase of the Accelerated Rotarod Task

PloS One
Haruna HirataTsuyoshi Koide

Abstract

Caspr3 (Contactin-associated protein-like 3, Cntnap3) is a neural cell adhesion molecule belonging to the Caspr family. We have recently shown that Caspr3 is expressed abundantly between the first and second postnatal weeks in the mouse basal ganglia, including the striatum, external segment of the globus pallidus, subthalamic nucleus, and substantia nigra. However, its physiological role remains largely unknown. In this study, we conducted a series of behavioral analyses on Capsr3-knockout (KO) mice and equivalent wild-type (WT) mice to investigate the role of Caspr3 in brain function. No significant differences were observed in most behavioral traits between Caspr3-KO and WT mice, but we found that Caspr3-KO mice performed poorly during the early phase of the accelerated rotarod task in which latency to falling off a rod rotating with increasing velocity was examined. In the late phase, the performance of the Caspr3-KO mice caught up to the level of WT mice, suggesting that the deletion of Caspr3 caused a delay in motor learning. We then examined changes in neural activity after training on the accelerated rotarod by conducting immunohistochemistry using antibody to c-Fos, an indirect marker for neuronal activity. Experience ...Continue Reading

References

May 31, 1976·Brain Research·R B ChronisterL E White
Jul 1, 1990·Trends in Neurosciences·M R DeLong
Oct 1, 1989·Trends in Neurosciences·R L AlbinJ B Penney
May 1, 1994·The Journal of Comparative Neurology·D G StandaertJ B Penney
Oct 1, 1996·Trends in Pharmacological Sciences·N J SucherS A Lipton
Mar 14, 1998·Proceedings of the National Academy of Sciences of the United States of America·A KarniL G Ungerleider
Sep 15, 1999·Nature·Y P TangJ Z Tsien
Dec 28, 1999·Brain Research. Brain Research Reviews·D CentonzeP Calabresi
Aug 2, 2000·Mammalian Genome : Official Journal of the International Mammalian Genome Society·T KoideT Shiroishi
Oct 29, 2000·Trends in Neurosciences·J A ObesoC W Olanow
Nov 9, 2000·Journal of Neurophysiology·M L Belleau, R A Warren
Dec 20, 2000·Proceedings of the National Academy of Sciences of the United States of America·Z SarnyaiM Toth
Apr 12, 2001·Neuropathology and Applied Neurobiology·K A Sieradzan, D M Mann
Jan 24, 2003·Annual Review of Pharmacology and Toxicology·Robert J WentholdRonald S Petralia
Sep 10, 2003·The Journal of Cell Biology·Sebastian PoliakElior Peles
Nov 20, 2003·Neuroscience Letters·Héctor Vargas-PérezJosé Luis Díaz
Apr 15, 2004·Neurobiology of Learning and Memory·Manuel M BuitragoAndreas R Luft
Jul 10, 2004·Current Biology : CB·Rui M CostaMiguel A L Nicolelis
Jul 23, 2004·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Andreas R LuftJörg B Schulz
Sep 3, 2004·Neurobiology of Learning and Memory·Carlos A Palencia, Michael E Ragozzino
Jul 28, 2005·The European Journal of Neuroscience·Henry H YinBernard W Balleine
Dec 31, 2005·Molecular Neurobiology·Andreas R Luft, Manuel M Buitrago
Jan 6, 2006·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Ingo Willuhn, Heinz Steiner
May 23, 2006·Nature Reviews. Neuroscience·Henry H Yin, Barbara J Knowlton
Jul 18, 2006·Mammalian Genome : Official Journal of the International Mammalian Genome Society·Walther TrautHeinz Winking
Oct 4, 2006·Proceedings of the National Academy of Sciences of the United States of America·Mai T DangYuqing Li
Jun 19, 2008·Annual Review of Neuroscience·Ann M Graybiel
Jan 16, 2009·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Tobias WächterJames Ashe
Sep 25, 2009·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Bernard W Balleine, John P O'Doherty
Oct 14, 2009·Experimental Brain Research·Tobias WächterAndreas R Luft
Mar 23, 2011·Current Biology : CB·Mitsunari AbeLeonardo G Cohen

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Citations

Dec 5, 2017·The Korean Journal of Physiology & Pharmacology : Official Journal of the Korean Physiological Society and the Korean Society of Pharmacology·Min Joon KimWoojin Kim
Apr 25, 2020·American Journal of Medical Genetics. Part a·Eleanor G LudingtonChristopher P Barnett
Apr 18, 2017·Nordic Journal of Psychiatry·Mitsuo OkitaShu-Ichi Ueno
Aug 5, 2017·Frontiers in Cellular Neuroscience·William C Spencer, Evan S Deneris

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BETA
genotyping

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Image EPM
Statview

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