Cassane diterpenes from the seed kernels of Caesalpinia sappan

Phytochemistry
Hai Xuan NguyenSuresh Awale

Abstract

Eight structurally diverse cassane diterpenes named tomocins A-H were isolated from the seed kernels of Vietnamese Caesalpinia sappan Linn. Their structures were determined by extensive NMR and CD spectroscopic analysis. Among the isolated compounds, tomocin A, phanginin A, F, and H exhibited mild preferential cytotoxicity against PANC-1 human pancreatic cancer cells under nutrition-deprived condition without causing toxicity in normal nutrient-rich conditions.

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Citations

Jun 21, 2016·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Han BaoLi-Gen Lin
Dec 15, 2016·Journal of Natural Products·Yuben QiaoYonghui Zhang
Oct 19, 2017·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Nai-Liang ZhuXu-Dong Xu
Sep 7, 2017·Natural Product Reports·James R Hanson
Apr 11, 2020·Natural Product Research·Min WangQiong-Shi Wu
Jun 5, 2020·Natural Product Research·Mai Thanh Thi NguyenNhan Trung Nguyen
Jun 24, 2020·Natural Product Research·Mai T T NguyenNhan T Nguyen
Apr 4, 2017·Phytotherapy Research : PTR·Muhammad Torequl Islam
Nov 4, 2020·Natural Product Research·Mai Thanh Thi NguyenNhan Trung Nguyen
Nov 21, 2020·Natural Product Research·Jiang YuantingLiang Hanqiao
Aug 3, 2021·Journal of Natural Products·Miao WangHuiyuan Gao
Jan 23, 2020·Journal of Natural Products·Mai T T NguyenNhan T Nguyen

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