Cassia alata L: potential role as anthelmintic agent against Hymenolepis diminuta.

Parasitology Research
S KunduLarisha M Lyndem

Abstract

The efficacy of Cassia alata against cestode Hymenolepis diminuta was evaluated in our study. Worms were maintained between rat model and beetle. Air-dried leaves of C. alata were subjected to ethanol extraction. Different concentrations (10-80 mg/ml) of the extract were prepared in phosphate buffer saline and tested on the parasite in vitro. Parasites treated with C. alata showed a decrease in motility with an increase in concentrations and complete immobilization took lesser time compared to control. The paralyzed parasites were further processed for electron microscopic studies. Ultrastructural micrographs revealed swelling of the tegument and blebbing on the tegumental surface throughout the body accompanied with destruction of microtriches and changes such as shrinkage in the scolex region. Depletion of parenchyma cells and destruction in the connective tissues along with sparsely cytoplasmic cytons were also observed, and these observations are similar with worms treated with a known drug praziquantel. These results may suggest that the plant leaves could be considered for controlling helminth infection and can represent a step forward in the search for alternative anthelmintic drug.

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Citations

Mar 4, 2014·International Journal of Molecular Sciences·Rong-Jyh LinChuan-Min Yen
Feb 16, 2016·Pharmaceutical Biology·Saptarshi RoyLarisha M Lyndem
Jan 17, 2015·Microscopy and Microanalysis : the Official Journal of Microscopy Society of America, Microbeam Analysis Society, Microscopical Society of Canada·Bishnupada Roy, Bikash R Giri
Sep 4, 2014·Asian Pacific Journal of Tropical Biomedicine·Suman KunduLarisha Mawkhleing Lyndem
Apr 6, 2017·Revista Do Instituto De Medicina Tropical De São Paulo·Dayane MoraesRosângela Maria Rodrigues
Nov 14, 2018·Microscopy and Microanalysis : the Official Journal of Microscopy Society of America, Microbeam Analysis Society, Microscopical Society of Canada·Bidisha UkilLarisha Mawkhlieng Lyndem
Mar 21, 2017·Journal of Parasitic Diseases : Official Organ of the Indian Society for Parasitology·S KunduLarisha Mawkhlieng Lyndem
Mar 10, 2020·Evidence-based Complementary and Alternative Medicine : ECAM·Oluwole Solomon OladejiDeborah Temitope Bankole
Jul 4, 2020·Molecular and Biochemical Parasitology·Saptarshi RoyLarisha M Lyndem
Jul 21, 2020·Heliyon·Sri FatmawatiMohd Fadzelly Abu Bakar
Jul 3, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Rambod AbiriSonia Malik

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Anthelmintics (ASM)

Anthelmintics or antihelminthics are a group of antiparasitic drugs that expel parasitic worms (helminths) and other internal parasites from the body by either stunning or killing them and without causing significant damage to the host. Discover the latest research on anthelmintics here.

Anthelmintics

Anthelmintics or antihelminthics are a group of antiparasitic drugs that expel parasitic worms (helminths) and other internal parasites from the body by either stunning or killing them and without causing significant damage to the host. Discover the latest research on anthelmintics here.