Abstract
The aim of this study was to determine of the effect of casticin, as an anti-inflammatory agent, on an acute lung inflammation in vivo model established through exposure to cigarette smoke (CS). Casticin is a phytochemical from Vitex species such as Vitex rotundifolia and Vitex agnus-castus that was recently shown to exert an anti-inflammatory effect in vivo. To demonstrate the effects of casticin, C57BL/6 mice were whole-body exposed to mainstream CS or fresh air for two weeks and treated with 1, 2, and 10mg/kg casticin via an i.p. injection. Immune cell infiltrations and cytokine productions were assessed from bronchoalveolar lavage Fluid (BALF), and lung histological analysis was performed. Treatment with casticin was observed to significantly inhibit the numbers of total cells, neutrophils, macrophages, and lymphocytes and reduce the levels of proinflammatory cytokines and chemokines in the BALF. In addition, casticin significantly decreased the infiltration of peribronchial and perivascular inflammatory cells and the epithelium thickness. The results of this study indicate that casticin has significant effects on the lung inflammation induced by CS in a mouse model. According to these outcomes, casticin may have therapeuti...Continue Reading
References
Sep 21, 2000·Journal of Ethnopharmacology·T Y ShinH M Kim
Oct 24, 2002·The European Respiratory Journal. Supplement·K F Chung
Dec 20, 2003·Respiratory Medicine·Enrica BucchioniPeter J Barnes
Dec 17, 2004·Pharmacological Reviews·Peter J Barnes
May 6, 2008·American Journal of Physiology. Lung Cellular and Molecular Physiology·Joanne L WrightAndrew Churg
Feb 11, 2009·The Journal of Allergy and Clinical Immunology·Timothy MainardiLeonard Bielory
May 2, 2009·The European Respiratory Journal·P J Barnes, B R Celli
Sep 1, 2009·Lancet·Peter M A CalverleyUNKNOWN M2-124 and M2-125 study groups
Dec 10, 2009·The Journal of Pharmacology and Experimental Therapeutics·Karin J StebbinsDaniel S Lorrain
Nov 3, 2010·Acta Pharmacologica Sinica·Qi YELu-ping QIN
Dec 31, 2011·Oriental Pharmacy and Experimental Medicine·Ravindra G Mali, Avinash S Dhake
Sep 12, 2012·Nutrition·Meng-Jing BaoQiang-Min Xie
Sep 10, 2013·BMC Complementary and Alternative Medicine·Kyung-Hwa JungHyunsu Bae
May 3, 2014·Experimental Lung Research·Saeed KolahianMohsen Hanifeh
Citations
Jul 28, 2016·European Journal of Pharmacology·Chunlei WangWenbo Wang
Aug 19, 2016·Journal of Natural Medicines·Chongyue QiuLixia Chen
Feb 13, 2018·The American Journal of Chinese Medicine·Woogyeong KimJinju Kim
Mar 24, 2016·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Zih-Yun WuJing-Gung Chung
Jun 8, 2018·Phytotherapy Research : PTR·Jiamei MaLinzhong Yu
Mar 7, 2018·Phytotherapy Research : PTR·Jiusheng Wang
Sep 17, 2017·Oncotarget·Ling ZhouHang Zheng
Dec 20, 2017·Oncotarget·Chian-Jiun Liou, Wen-Chung Huang
Jan 4, 2020·Inflammation·Jun ChuZhongmin Zhang
Nov 19, 2018·Naunyn-Schmiedeberg's Archives of Pharmacology·Zhe QiaoWei Zhang
Jun 17, 2020·Particle and Fibre Toxicology·Tuukka IhantolaPasi I Jalava
Jul 19, 2020·International Journal of Molecular Sciences·Axelle Septembre-MalaterrePhilippe Gasque
Jan 11, 2017·Cancer Cell International·Xiao-Ling SongJun Gu
Oct 19, 2017·International Journal of Molecular Medicine·Jae-Won LeeKyung-Seop Ahn
Jul 3, 2018·Frontiers in Pharmacology·Chian-Jiun LiouWen-Chung Huang
Mar 1, 2019·Cancers·Jong Hyun LeeKwang Seok Ahn
Jul 30, 2019·Journal of Food Biochemistry·Sabrin Ragab Mohamed IbrahimMarwa Abd-Elmoneim El-Kholy
Oct 13, 2018·Molecular Biology Reports·Balraj Singh GillSanjeev Kumar
Jan 19, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Zheng-Yu ChengJing-Gung Chung
Jan 7, 2019·European Journal of Medicinal Chemistry·Priscila Baltazar Gonçalves, Nelilma Correia Romeiro
Nov 26, 2020·Drug Design, Development and Therapy·Jie LiRongchang Chen
Jan 26, 2021·Evidence-based Complementary and Alternative Medicine : ECAM·Yang YangZheng Li
Aug 8, 2021·Foods·Bei ZhangWeiping Jin