Casting a genome-wide net for learning mutants

Neuron
Evan L Ardiel, Catharine H Rankin

Abstract

Wolman et al. (2015) report a forward genetic screen in zebrafish that implicated pregnancy-associated plasma protein-aa in habituation of the acoustic startle response. PAPP-AA is expressed in the underlying circuit, including Mauthner cells, and regulates habituation via IGF signaling.

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