Casting A Wide Net On Surgery: The Central Role of Neutrophil Extracellular Traps.

Annals of Surgery
Jules H EustacheJonathan D Spicer

Abstract

: Since their discovery, neutrophil extracellular traps (NETs) have been implicated in a broad array of functions, both beneficial and detrimental to the host. Indeed, NETs have roles in infection, sepsis, wound healing, thrombotic disease, and cancer propagation, all of which are directly implicated in the care of surgical patients. Here we provide an updated review on the role of NETs in the perioperative period with specific emphasis on perioperative infections, wound healing, vascular complications, cancer propagation, as well as discussing ongoing, and future therapeutic targets. Surgeons will benefit from understanding the latest discoveries in neutrophil biology and how these novel functions affect the care of surgical patients. Furthermore, novel anti-NET therapies are being developed which may have profound effects on the care of surgical patients.

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Citations

Aug 9, 2020·Local and Regional Anesthesia·Juan P CataMaria F Ramirez
Jan 26, 2021·Frontiers in Pediatrics·Michaela KlinkeMichael Boettcher
May 15, 2021·Nature Communications·Surashri Shinde-JadhavWassim Kassouf
Jun 9, 2021·Journal of Gastrointestinal Surgery : Official Journal of the Society for Surgery of the Alimentary Tract·Luke V SelbyDavid J Douin

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Methods Mentioned

BETA
biopsy

Clinical Trials Mentioned

NCT03368092

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