Casting a Wider NET: An Unusual Cause of Acute Liver Failure in a Pregnant Patient.

Digestive Diseases and Sciences
Jasleen GrewalGina Choi

Abstract

We present a case patient in her second trimester of pregnancy who developed acute liver failure from metastatic neuroendocrine tumor (NET). Although she underwent prompt induction of a non-viable fetus due to initial concerns of hemolysis, elevated liver enzymes, and low platelet count syndrome, her liver function continued to deteriorate postpartum. She was subsequently transferred to our institution in order to undergo further evaluation that included a transjugular liver biopsy and subsequent diagnosis of high-grade NET. She was given salvage carboplatin-based chemotherapy, as she was not a liver transplant candidate. Unfortunately, the patient expired from cardiovascular collapse as a component of multiorgan failure.

References

Jun 21, 2008·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·James C YaoDouglas B Evans
Nov 26, 2009·Obstetrics and Gynecology·Mina Abbassi-GhanavatiF Gary Cunningham
Feb 18, 2010·Lancet·Deepak JoshiMichael A Heneghan
Mar 15, 2011·Journal of Hepatology·Scott L Friedman
Apr 19, 2017·Journal of Hepatology·UNKNOWN European Association for the Study of the Liver. Electronic address: easloffice@easloffice.euMauro Bernardi
Oct 1, 2014·Hepatic Oncology·Louise BarbierJacques Belghiti

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