Castleman's disease and mesangial proliferative glomerulonephritis: the role of interleukin-6

Nephron
S L LuiT M Chan

Abstract

Renal complications of Castleman's disease (angiofollicular lymph node hyperplasia) are uncommon. The reported cases are very heterogeneous and their renal pathology ranged from minimal change disease, mesangial proliferative glomerulonephritis, to amyloidosis. We have previously reported two cases of Castleman's disease with renal complications. We now present two more such cases. In contrast to other reports, all our cases are of the plasma cell type and their renal pathology showed remarkable similarities, namely mesangial proliferation, interstitial plasma cell infiltration and negative immunofluorescence. The level of serum interleukin-6 (IL-6) in both patients was elevated at presentation and came down with immunosuppressive therapy.

Citations

May 5, 2005·Current Treatment Options in Oncology·Angela Dispenzieri, Morie A Gertz
Jan 29, 2008·International Journal of Hematology·Yuriko Morita-HoshiNobuo Nara
Jul 20, 1999·Kidney International·P M Ronco
Jan 25, 2005·Nephrology·Kay-Tai LeungChun-Sang Li
Nov 13, 2007·Nephrology·Antoni SydorMichał Nowicki
Oct 22, 2011·Italian Journal of Pediatrics·Piero FarruggiaPaolo D'Angelo
Jul 27, 2006·International Journal of Hematology·Noboru YamagataAkiyoshi Miwa
Jul 25, 2006·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Susan UthupManju Leela
Apr 29, 2006·Journal of the European Academy of Dermatology and Venereology : JEADV·C PerdaensJ Sennesael
Jul 2, 2014·Otolaryngologia polska. The Polish otolaryngology·Dastan TemirbekovFatma Tulin Kayhan
Jun 28, 2001·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·S CurioniD Cusi
Feb 19, 2010·The Gulf Journal of Oncology·A M Al-AmriK Q Ghallab
Dec 14, 2021·Journal of Clinical Rheumatology : Practical Reports on Rheumatic & Musculoskeletal Diseases·Taro HorinoOsamu Ichii

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